Results 11 to 20 of about 391,856 (245)
LC/MS and LC/MS/MS determination of protein tryptic digests [PDF]
Journal of the American Society for Mass Spectrometry, 1990 Tryptic digests were analyzed by means of online microbore liquid chromatography combined with mass spectrometry (LC/MS) for some common proteins. Following conventional enzymatic digestion with trypsin, the freeze-dried residues were dissolved in high-performance liquid chromatography (HPLC) eluent and subjected to gradient reversed-phase microbore ...
Huang, Eric C., Henion, Jack D.
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LC-MS-based metabolomics [PDF]
Molecular BioSystems, 2011 Abstract Metabolomics aims at identification and quantitation of small molecules involved in metabolic reactions. LC-MS has enjoyed a growing popularity as the platform for metabolomic studies due to its high throughput, soft ionization, and good coverage of metabolites.
Bin, Zhou +3 more
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LC-MS (/MS) in Clinical Toxicology Screening Methods
CHIMIA, 2012 Toxicological screening is the analysis of biological samples to detect and identify unknown compounds. The high selectivity and sensitivity of liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS ...
Véronique Viette +2 more
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Liquid Chromatography–Tandem Mass Spectrometry in Newborn Screening Laboratories
International Journal of Neonatal Screening, 2022 Tandem mass spectrometry (MS/MS) is the most universal platform currently available for the analysis of enzymatic activities and biomarkers in dried blood spots (DBS) for applications in newborn screening (NBS).
Michael H. Gelb +25 more
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Largazole Pharmacokinetics in Rats by LC-MS/MS
Marine Drugs, 2014 A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated.
Mingming Yu +9 more
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BMC Research Notes, 2017 Objective Thyroglobulin (Tg) measurements assess recurrence in post-thyroidectomy thyroid cancer patients. Tg measurements by enzyme immunoassays (EIA) can be falsely elevated by interference from Tg autoantibodies (TgAb).
Sarah E. Wheeler +7 more
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Stable gradient nanoflow LC-MS [PDF]
Journal of the American Society for Mass Spectrometry, 2005 This paper demonstrates improved nanoflow LC-MS performance on a QqTOF instrument with the incorporation of a heated nanoflow interface (particle discriminator) and a nebulizer assisted sprayer. It is shown that the nebulizer broadens the usable range of electrospray potentials, simplifying the tuning procedure, particularly for negative mode nanoflow ...
Schneider, Bradley B. +3 more
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Application of LC–MS/MS in the Mycotoxins Studies
Toxins, 2020 Mycotoxins are secondary metabolites produced by fungi of different species (mainly Aspergillus, Fusarium, and Penicillium) with toxic effects for humans and animals that can contaminate food and feed [...]
Laura Gámiz-Gracia +2 more
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Emerging ContaminantsA targeted method for the quantitative determination of PFAS residues in fish feed and marine aquaculture fish species was developed and validated in the current study.
Ourania Koloka +4 more
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LC-MS/MS Method for Serum Creatinine: Comparison with Enzymatic Method and Jaffe Method. [PDF]
PLoS ONE, 2015 Accurate quantification of creatinine (Cre) is important to estimate glomerular filtration rate (GFR). Differences among various methods of Cre quantification were previously noted.
Meixian Ou +7 more
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