Results 11 to 20 of about 374,900 (245)
Explaining unexplained hypoglycemia: How LC-MS/MS can help
Practical Laboratory Medicine, 2022 Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By
M.T. Ackermans +3 more
doaj +1 more source
Liquid Chromatography–Tandem Mass Spectrometry in Newborn Screening Laboratories
International Journal of Neonatal Screening, 2022 Tandem mass spectrometry (MS/MS) is the most universal platform currently available for the analysis of enzymatic activities and biomarkers in dried blood spots (DBS) for applications in newborn screening (NBS).
Michael H. Gelb +25 more
doaj +1 more source
LC-MS-based metabolomics [PDF]
Molecular BioSystems, 2011 Abstract Metabolomics aims at identification and quantitation of small molecules involved in metabolic reactions. LC-MS has enjoyed a growing popularity as the platform for metabolomic studies due to its high throughput, soft ionization, and good coverage of metabolites.
Bin, Zhou +3 more
openaire +2 more sources
LC-MS (/MS) in Clinical Toxicology Screening Methods
CHIMIA, 2012 Toxicological screening is the analysis of biological samples to detect and identify unknown compounds. The high selectivity and sensitivity of liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS ...
Véronique Viette +2 more
doaj +1 more source
Largazole Pharmacokinetics in Rats by LC-MS/MS
Marine Drugs, 2014 A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated.
Mingming Yu +9 more
doaj +1 more source
BMC Research Notes, 2017 Objective Thyroglobulin (Tg) measurements assess recurrence in post-thyroidectomy thyroid cancer patients. Tg measurements by enzyme immunoassays (EIA) can be falsely elevated by interference from Tg autoantibodies (TgAb).
Sarah E. Wheeler +7 more
doaj +1 more source
Application of LC–MS/MS in the Mycotoxins Studies
Toxins, 2020 Mycotoxins are secondary metabolites produced by fungi of different species (mainly Aspergillus, Fusarium, and Penicillium) with toxic effects for humans and animals that can contaminate food and feed [...]
Laura Gámiz-Gracia +2 more
doaj +1 more source
Stable gradient nanoflow LC-MS [PDF]
Journal of the American Society for Mass Spectrometry, 2005 This paper demonstrates improved nanoflow LC-MS performance on a QqTOF instrument with the incorporation of a heated nanoflow interface (particle discriminator) and a nebulizer assisted sprayer. It is shown that the nebulizer broadens the usable range of electrospray potentials, simplifying the tuning procedure, particularly for negative mode nanoflow ...
Schneider, Bradley B. +3 more
openaire +2 more sources
LC-MS/MS Method for Serum Creatinine: Comparison with Enzymatic Method and Jaffe Method. [PDF]
PLoS ONE, 2015 Accurate quantification of creatinine (Cre) is important to estimate glomerular filtration rate (GFR). Differences among various methods of Cre quantification were previously noted.
Meixian Ou +7 more
doaj +1 more source
Comparative Analysis of Liquid Chromatography-Tandem Mass Spectrometry and Radioimmunoassay in Determining Plasma Aldosterone Concentration and Plasma Renin Activity for Primary Aldosteronism Screening [PDF]
Endocrinology and MetabolismLiquid chromatography-tandem mass spectrometry (LC-MS/MS) accurately measures plasma aldosterone concentration (PAC), but its correlation with radioimmunoassay (RIA), equivalent RIA levels, and optimal cutoff for PAC and aldosterone-to-renin ratio (ARR ...
So Yoon Kwon +3 more
doaj +1 more source