Results 41 to 50 of about 23,319 (231)

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Medical Fabrics with Non‐Antibiotic, Supramolecular Antimicrobial Coatings: A Preventive Approach to Combat Biofilm Formation and Bacterial Dissemination

Advanced Healthcare Materials, EarlyView.
The study presents an antibiotic‐free strategy using medical fabrics coated with supramolecular assemblies of polyarginine and hyaluronic acid. These coatings showed strong antimicrobial and anti‐biofilm activity in vitro and in vivo, achieving major bacterial load reductions, including against MRSA.
Adjara Diarrassouba, Abdessalem Rekiki, Cécile Loubière, Sabine Kuchler‐Bopp, Lauriane Petit, Cynthia Calligaro, Derry Mercer, Aurore Gaudin, Naomi Canourgues, Emilie Adicéam, Benoit Beitz, Jeremy Welsch, Annabelle Vigué, Markus j. Kettel, Michael Karl, Chloé Guilbaud‐Chéreau, Philippe Lavalle, Nihal Engin Vrana, Skander Hathroubi   +18 more
wiley   +1 more source

Wound Geometry Determines Whether Aligned‐Fiber Scaffolds Accelerate or Impede Diabetic Wound Healing: A Biased Random Walk Analysis

Advanced Healthcare Materials, EarlyView.
Wound closure is governed by geometry‐orientation coupling: aligned fibers speed migration along their axis but hinder perpendicular advance. In vivo diabetic wound experiments with composition‐matched fibrin, combined with an anisotropic diffusion (biased random‐walk) model, quantify this trade‐off and generate a healing landscape.
Yin‐Yuan Huang, Xiangjun Peng, Yuxuan Huang, Kunkoo Kim, Chengli Li, Peilun Hu, Sean J. Wang, Rohan Avula, Chun‐Yi Yang, Pengchao Ma, Shuhui Yang, Shumeng Jiang, Guy M. Genin, Xiumei Wang   +13 more
wiley   +1 more source

The Usefulness of Line-Field Confocal Optical Coherence Tomography in Monitoring Epidermal Changes in Atopic Dermatitis in Response to Treatment: A Pilot Study

Diagnostics
Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Due to its high prevalence, considerable morbidity, and chronicity, there is a need for the accurate in vivo evaluation of treatment efficacy.
Zuzanna Dryżałowska, Leszek Blicharz, Agnieszka Michalczyk, Jan Koscian, Małgorzata Maj, Joanna Czuwara, Lidia Rudnicka   +6 more
doaj   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Unusual site presentation of dermatitis herpetiformis: line-field confocal optical coherence tomography for effective management

Dermatology Reports
Dermatitis herpetiformis (DH) is an uncommon autoimmune blistering skin disorder linked to gluten sensitivity. This report describes the line-field confocal optical coherence tomography (LC-OCT) features in a DH case, correlating with histopathological ...
Luca Bettolini, Stefano Bighetti, Sara Rovaris, Iacopo Ghini, Vincenzo Maione   +4 more
doaj   +1 more source

Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study

BMC Ophthalmology, 2019
Background To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters.
Flavio S. Lopes, Igor Matsubara, Izabela Almeida, Syril K. Dorairaj, Roberto M. Vessani, Augusto Paranhos Jr, Tiago S. Prata   +6 more
doaj   +1 more source

A simple method for sphingolipid analysis of tissues embedded in optimal cutting temperature compound[S]

Journal of Lipid Research, 2020
MS-assisted lipidomic tissue analysis is a valuable tool to assess sphingolipid metabolism dysfunction in disease. These analyses can reveal potential pharmacological targets or direct mechanistic studies to better understand the molecular underpinnings ...
Timothy D. Rohrbach, April E. Boyd, Pamela J. Grizzard, Sarah Spiegel, Jeremy Allegood, Santiago Lima   +5 more
doaj   +1 more source

Artificial intelligence‐based PRO score assessment in actinic keratoses from LC‐OCT imaging using Convolutional Neural Networks

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2023
SummaryBackground and ObjectivesThe histological PRO score (I–III) helps to assess the malignant potential of actinic keratoses (AK) by grading the dermal‐epidermal junction (DEJ) undulation. Line‐field confocal optical coherence tomography (LC‐OCT) provides non‐invasive real‐time PRO score quantification.
Thamm, Janis R., Daxenberger, Fabia, Viel, Théo, Gust, Charlotte, Eijkenboom, Quirine, French, Lars E., Welzel, Julia, Sattler, Elke C., Schuh, Sandra   +8 more
openaire   +3 more sources

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source