Results 261 to 270 of about 91,527 (300)

Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS

Journal of Pharmaceutical and Biomedical Analysis, 2017
Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous ...
Ahmad Abu-awwad, Tawfiq Arafat, Oliver J. Schmitz   +2 more
openaire   +3 more sources

Chemical profiling and comparative analysis of different parts of Asarum heterotropoides using SPME-GC-QTOF-MS and LC- Orbitrap -MS

Journal of Pharmaceutical and Biomedical Analysis
Asari radix et rhizoma is the sole plant from the Aristolochiaceae family officially sanctioned for medicinal in China, primarily employed for treating colds and headaches, and is widely utilized in clinical practice. Initially, the entire plant was specified for medicinal use, but since 2005, the authorized part has been restricted to the roots and ...
Yun-Shu, Hu, Jian-Qing, Zhang, Meng, Xu, Huan-Ya, Yang, Chun-Xiang, Liu, Yun, Li, Qi-Rui, Bi, Yang, Yang, Qin-Hua, Chen, De-An, Guo   +9 more
openaire   +2 more sources

LC-Orbitrap MS analysis of the glycation modification effects of ovalbumin during freeze-drying with three reducing sugar additives

Food Chemistry, 2018
In general, the reducing sugars were extensively utilized as additives to prevent denaturation and inactivation during the freeze-drying process. However, different additives have unequal protective effects on the protein conformation. To evaluate the mechanism of protection the protein structure using different additives in the freeze-drying process ...
Yang Chen, Zong-cai Tu, Hui Wang, Guang-xian Liu, Zi-wei Liao, Lu Zhang   +5 more
openaire   +2 more sources

Comprehensive Metabolic Profiling of Resigratinib, a Novel FGFR Inhibitor, Using Integrated LC–MS/MS and LC‐Orbitrap‐HRMS

Rapid Communications in Mass Spectrometry
ABSTRACT Rationale Resigratinib, a potent fibroblast growth factor receptor (FGFR) inhibitor, is under clinical development for solid tumors such as cholangiocarcinoma. However, data on its hepatic metabolism remain limited.
Xiaoxia An, Yanting Mao, Ali Fan, Ting Ma   +3 more
openaire   +1 more source

Simultaneous determination of nicotine, cotinine, and nicotine N-oxide in human plasma, semen, and sperm by LC-Orbitrap MS

Analytical and Bioanalytical Chemistry, 2016
Nicotine (Nic) distribution in human fluids and tissues has a deleterious effect on human health. In addition to its poisoning profile, Nic may contribute to the particular impact of smoking on human reproduction. Although present in seminal fluid, still nobody knows whether nicotine is available in sperm or not.
Abu-Awwad, Ahmad, Arafat, Tawfiq, Schmitz, Oliver J.   +2 more
openaire   +2 more sources

[Study on proteins in Guangdilong by nano LC/orbitrap fusion lumos HR-MS].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
In the present study,fresh Guangdilong( GD),originating from Pheretima aspergillum,was taken as the object. The total proteins from GD were firstly separated by SDS-PAGE according to their molecular weights and in-gel digestion was then performed.After that,the peptides were analyzed by nano LC/orbitrap fusion lumos high resolution mass spectrometry ...
Hong-Shuang, Dong, Jing-Xian, Zhang, Qing, Hu, Yan-Chun, Wang, Jian, Sun, Su, Zhang, Hong, Yu, Rui, Feng, Xiu-Hong, Mao, Shen, Ji   +9 more
openaire   +1 more source

In vitro and in vivo human metabolism of a synthetic cannabinoid EAM-2201 detected by LC–quadrupole-ion trap-MS/MS and high-resolution LC–Orbitrap-MS/MS

Forensic Toxicology, 2019
The aim of this study is to characterize the metabolites of EAM-2201 in human hepatocytes obtained in vitro and those in liver and urine specimens obtained in vivo from the autopsy of an EAM-2201 abuser. EAM-2201 was incubated with human hepatocytes for 3 h in a CO2 incubator and the metabolites of EAM-2201 were produced.
Kayoko Minakata, Itaru Yamagishi, Koutaro Hasegawa, Hideki Nozawa, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe   +7 more
openaire   +1 more source

Metabolic Profiling of Canertinib: A Comprehensive Cross‐Species Investigation Using Advanced UPLC‐MS/MS and LC‐Orbitrap‐HRMS Techniques

Biomedical Chromatography
ABSTRACTCanertinib is an EGFR tyrosine kinase inhibitor intended for the treatment of leukemia and non–small cell lung cancer. This study described a UPLC‐MS/MS method for quantitatively assessing the metabolic stability of canertinib in liver microsomes.
Weiqi Yuan, Gang Shi, Lantu Gou, Jinliang Yang   +3 more
openaire   +1 more source

The use of LC-Orbitrap MS for the detection of Fusarium masked mycotoxins: the case of type A trichothecenes

World Mycotoxin Journal, 2012
‘Masked mycotoxins’ (mycotoxin glucosides) derived from type A trichothecenes (T-2 toxin and HT-2 toxin) were detected in commercially available maize powder reference material. These novel glucosides were identified as T-2 toxin-glucoside (T2-Glc) and HT-2 toxin-glucoside (HT2-Glc) on the basis of accurate mass measurements of characteristic ions and ...
H. Nakagawa, S. Sakamoto, Y. Sago, M. Kushiro, H. Nagashima   +4 more
openaire   +1 more source

Metabolic profiling of 5- Methoxy-N,N-diallyltryptamine in human liver microsomes and zebrafish using LC-Orbitrap MS

Journal of Chromatography B
The metabolic profiles of tryptamine-derived new psychoactive substance 5-Methoxy-N, N-diallyltryptamine (5-MeO-DALT) were investigated using both zebrafish and human liver microsome models. The ultra-high performance liquid chromatography Q Exactive Quadrupole-Orbitrap high resolution mass spectrometer (UPLC-Q-Orbitrap-HRMS) was employed to analyze ...
Liang, Meng, Yanjiao, Wang, Chenhao, Zhong, Sen, Zhao   +3 more
openaire   +2 more sources