Results 271 to 280 of about 313,222 (315)

Application of nano-LC - nano-ESI - Orbitrap-MS for trace determination of four priority PFAS in food products considering recently established tolerable weekly intake (TWI) limits.

Analytica Chimica Acta, 2023
An analytical method was developed and validated for the analysis of four priority perfluoroalkyl substances (PFAS), namely, perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexanesulfonic acid (PFHxS), and perfluorooctanesulfonate (
D. Začs, D. Fedorenko, E. Pasecnaja, V. Bartkevičs   +3 more
semanticscholar   +1 more source

Identification of post-mortem paliperidone metabolite in human blood by LC-Q-Orbitrap-MS.

Journal of Analytical Toxicology, 2023
Paliperidone is a widely used antipsychotic agent detected in many fatal intoxications and suicide cases. In forensic toxicology, the accurate determination of blood paliperidone concentrations is required to prove death by paliperidone poisoning ...
Yoshikazu Yamagishi, G. Inokuchi, Yumi Hoshioka, Sayaka Nagasawa, H. Iwase, Y. Ogra   +5 more
semanticscholar   +1 more source

Critical comparison of direct analysis in real time orbitrap mass spectrometry (DART-Orbitrap MS) towards liquid chromatography mass spectrometry (LC-MS) for mycotoxin detection in cereal matrices

Food Control, 2022
Foodstuffs contaminated by mycotoxins have been reported around the globe resulting in significant financial losses and health-threating cases due to dietary exposure.
A. Tsagkaris, V. Hrbek, Z. Džuman, J. Hajšlová   +3 more
semanticscholar   +1 more source

Instrument-type effects on chemical isotope labeling LC-MS metabolome analysis: Quadrupole time-of-flight MS vs. Orbitrap MS.

Analytica Chimica Acta, 2022
Chemical isotope labeling (CIL) LC-MS is a powerful tool for metabolome analysis with markedly improved metabolomic coverage and quantification accuracy over the conventional LC-MS technique.
Chu-Fan Wang, Liang Li
semanticscholar   +1 more source

Metabolic Profiling of Sitravatinib in Rat and Human Liver Microsomes Using LC–MS/MS and LC–Orbitrap–HRMS

Rapid Communications in Mass Spectrometry
ABSTRACT Rationale Sitravatinib is a receptor tyrosine kinase inhibitor that has been developed for the treatment of advanced nonsmall‐cell lung cancer (NSCLC) and urothelial carcinoma. This study aimed at developing an integrated LC–MS/MS and LC–Orbitrap–HRMS platform for evaluating the ...
Shan Xu, Ying Zhu, Wenxia Liu, Guanging Bao, Linfei Li   +4 more
openaire   +2 more sources

Detection of a newFusariummasked mycotoxin in wheat grain by high-resolution LC–Orbitrap™ MS

Food Additives & Contaminants: Part A, 2011
A new Fusarium mycotoxin glucoside, fusarenon X-glucoside (FUXGlc), is reported for the first time in wheat grain that was artificially infected with Fusarium fungi. This new glucoside was identified using LC Orbitrap high-resolution mass spectrometry (LC-Orbitrap MS) analysis on the basis of accurate mass measurement of characteristic ions and MS/MS ...
H, Nakagawa, K, Ohmichi, S, Sakamoto, Y, Sago, M, Kushiro, H, Nagashima, M, Yoshida, T, Nakajima   +7 more
openaire   +2 more sources

Comprehensive Metabolic Profiling of Resigratinib, a Novel FGFR Inhibitor, Using Integrated LC–MS/MS and LC‐Orbitrap‐HRMS

Rapid Communications in Mass Spectrometry
ABSTRACT Rationale Resigratinib, a potent fibroblast growth factor receptor (FGFR) inhibitor, is under clinical development for solid tumors such as cholangiocarcinoma. However, data on its hepatic metabolism remain limited.
Xiaoxia An, Yanting Mao, Ali Fan, Ting Ma   +3 more
openaire   +2 more sources

Metabolic Profiling of Canertinib: A Comprehensive Cross‐Species Investigation Using Advanced UPLC‐MS/MS and LC‐Orbitrap‐HRMS Techniques

Biomedical Chromatography
ABSTRACTCanertinib is an EGFR tyrosine kinase inhibitor intended for the treatment of leukemia and non–small cell lung cancer. This study described a UPLC‐MS/MS method for quantitatively assessing the metabolic stability of canertinib in liver microsomes.
Weiqi Yuan, Gang Shi, Lantu Gou, Jinliang Yang   +3 more
openaire   +2 more sources

[Study on proteins in Guangdilong by nano LC/orbitrap fusion lumos HR-MS].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
In the present study,fresh Guangdilong( GD),originating from Pheretima aspergillum,was taken as the object. The total proteins from GD were firstly separated by SDS-PAGE according to their molecular weights and in-gel digestion was then performed.After that,the peptides were analyzed by nano LC/orbitrap fusion lumos high resolution mass spectrometry ...
Hong-Shuang, Dong, Jing-Xian, Zhang, Qing, Hu, Yan-Chun, Wang, Jian, Sun, Su, Zhang, Hong, Yu, Rui, Feng, Xiu-Hong, Mao, Shen, Ji   +9 more
openaire   +1 more source

In vitro and in vivo human metabolism of a synthetic cannabinoid EAM-2201 detected by LC–quadrupole-ion trap-MS/MS and high-resolution LC–Orbitrap-MS/MS

Forensic Toxicology, 2019
The aim of this study is to characterize the metabolites of EAM-2201 in human hepatocytes obtained in vitro and those in liver and urine specimens obtained in vivo from the autopsy of an EAM-2201 abuser. EAM-2201 was incubated with human hepatocytes for 3 h in a CO2 incubator and the metabolites of EAM-2201 were produced.
Kayoko Minakata, Itaru Yamagishi, Koutaro Hasegawa, Hideki Nozawa, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe   +7 more
openaire   +1 more source