Results 61 to 70 of about 91,527 (300)

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Accurate and reliable quantification of 25-hydroxy-vitamin D species by liquid chromatography high-resolution tandem mass spectrometry

Journal of Lipid Research, 2015
In general, mass spectrometric quantification of small molecules in routine laboratory testing utilizes liquid chromatography coupled to low mass resolution triple-quadrupole mass spectrometers (QQQs).
Gerhard Liebisch, Silke Matysik
doaj   +1 more source

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. [PDF]

, 2017
Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins ...
Ahmad, Alla S, Bennett, Eric J, Clauser, Karl R, Gu, Hongbo, Komives, Elizabeth A, Leonard, Marilyn, Lumpkin, Ryan J, Meyer, Jesse G, Zhu, Yiying   +8 more
core   +2 more sources

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Multiomics-based assessment of the impact of airflow on diverse plant callus cultures

Scientific Data
Plant cell culture has multiple applications in biotechnology and horticulture, from plant propagation to the production of high-value biomolecules. However, the interplay between cellular diversity and ambient conditions influences the metabolism of ...
June-Sik Kim, Muneo Sato, Mikiko Kojima, Muchamad Imam Asrori, Yukiko Uehara-Yamaguchi, Yumiko Takebayashi, Thi Nhung Do, Thi Yen Do, Kieu Oanh Nguyen Thi, Hitoshi Sakakibara, Keiichi Mochida, Shinjiro Ogita, Masami Yokota Hirai   +12 more
doaj   +1 more source

Proteomics Evaluation of Semen of Clinically Healthy Beagle-Breed Dogs

Veterinary Sciences, 2022
The objectives of the present work were to evaluate the semen of dogs by means of proteomics methods and to compare with proteomics results of the blood of the animals, in order to increase available knowledge on the topic and present relevant reference ...
Pagona G. Gouletsou, George Th. Tsangaris, Eleni I. Katsarou, Maria V. Bourganou, Mariana S. Barbagianni, Athina P. Venianaki, Efterpi Bouroutzika, Athanasios K. Anagnostopoulos, George C. Fthenakis, Angeliki I. Katsafadou   +9 more
doaj   +1 more source

Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer [PDF]

, 2015
Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which
A Franceschini, AA Adjei, Arnhild Grothey, B Gyorffy, Cancer Genome Atlas Network, F Yan, F Yan, Georgios Giamas, H Xing, H Zhang, H Zhang, H Zhang, HR Xing, Hua Zhang, I Youlyouz-Marfak, J Cox, J Cox, J Lozano, J Stebbing, J Wielemaker, J Xu, J Zhang, Joao Nunes, Justin Stebbing, JV Olsen, K Kornfeld, L Hannesdottir, M Alcoceba, M Ashburner, M Kim, M Sundaram, M Therrien, M Therrien, Nicos Angelopoulos, NR Michaud, O Tacar, P Tymoszuk, PJ Klutho, R Kaneno, S Datta, S Falcon, S Zhu, Y Cao, Y Pommier, Y Xu, Y Zhang, Y Zhang, Yichen Xu, YJ Jeon   +48 more
core   +3 more sources

Quantitative profiling of the human substantia nigra proteome from laser-capture microdissected FFPE tissue [PDF]

, 2020
Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens.
Griesser, Eva, Lamond, Angus I., Lenter, Martin, Stierstorfer, Birgit, Ten Have, Sara, Wyatt, Hannah   +5 more
core   +3 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

A Method for Simultaneous Determination of 20 Fusarium Toxins in Cereals by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry with a Pentafluorophenyl Column

Toxins, 2015
A high-resolution liquid chromatography-Orbitrap mass spectrometry (LC-Orbitrap MS) method was developed for simultaneous determination of 20 Fusarium toxins (nivalenol, fusarenon-X, deoxynivalenol, 3-acetyl deoxynivalenol, 15-acetyl deoxynivalenol, HT-2
Masayoshi Tamura, Naoki Mochizuki, Yasushi Nagatomi, Koichi Harayama, Akira Toriba, Kazuichi Hayakawa   +5 more
doaj   +1 more source