Results 61 to 70 of about 313,222 (315)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Comparative study on phytosterol oxidation products determination in high oleic sunflower oil by using cholesterol oxidation products or purified phytosterol oxidation products as reference materials

Journal of Agriculture and Food Research
Phytosterols received great interest over the last decade due to their capacity to compete with cholesterol absorption during digestion. However, phytosterols can be oxidized resulting in oxidation products (phytosterol oxidation products, POPs), which ...
Ambra Bonciolini, Annalisa Vissio, Raffaele Calaminici, Emanuele Forte, Vladimiro Cardenia   +4 more
doaj   +1 more source

Multistage Detection of Tetrodotoxin Traces in Diodon hystrix Collected in El Salvador

Toxins, 2023
This study describes a multistage methodology to detect minute amounts of tetrodotoxin in fishes, a plan that may be broadened to include other marine organisms. This methodology was applied to porcupinefish (Diodon hystrix) collected in Punta Chiquirín,
Juan Carlos Fuentes-Monteverde, Marvin J. Núñez, Oscar Amaya-Monterosa, Morena L. Martínez, Jaime Rodríguez, Carlos Jiménez   +5 more
doaj   +1 more source

Pilot-plant scale extraction of phenolic compounds from grape canes: Comprehensive characterization by LC-ESI-LTQ-Orbitrap-MS.

Food Research International, 2021
Grape canes, also named vine shoots, are well-known viticultural byproducts containing high levels of phenolic compounds, which are associated with a broad range of health benefits. In this work, grape canes (Vitis vinifera cv. Pinot noir) were extracted
Danilo Escobar-Avello, C. Mardones, V. Sáez, S. Riquelme, D. von Baer, R. Lamuela-Raventós, A. Vallverdú-Queralt   +6 more
semanticscholar   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multiomics-based assessment of the impact of airflow on diverse plant callus cultures

Scientific Data
Plant cell culture has multiple applications in biotechnology and horticulture, from plant propagation to the production of high-value biomolecules. However, the interplay between cellular diversity and ambient conditions influences the metabolism of ...
June-Sik Kim, Muneo Sato, Mikiko Kojima, Muchamad Imam Asrori, Yukiko Uehara-Yamaguchi, Yumiko Takebayashi, Thi Nhung Do, Thi Yen Do, Kieu Oanh Nguyen Thi, Hitoshi Sakakibara, Keiichi Mochida, Shinjiro Ogita, Masami Yokota Hirai   +12 more
doaj   +1 more source

Accurate and reliable quantification of 25-hydroxy-vitamin D species by liquid chromatography high-resolution tandem mass spectrometry

Journal of Lipid Research, 2015
In general, mass spectrometric quantification of small molecules in routine laboratory testing utilizes liquid chromatography coupled to low mass resolution triple-quadrupole mass spectrometers (QQQs).
Gerhard Liebisch, Silke Matysik
doaj   +1 more source

QuEChERS-Based Methodology for the Screening of Alkylphenols and Bisphenol A in Dairy Products Using LC-LTQ/Orbitrap MS

Applied Sciences, 2021
A simple methodology was developed for the determination of four Endocrine Disrupting Chemicals (EDCs) in dairy products. The EDCs included alkylphenols (4-tert-octylphenol, technical nonylphenol isomers, 4-nonylphenol) and bisphenol-A.
V. Boti, Vasiliki Kobothekra, T. Albanis, I. Konstantinou   +3 more
semanticscholar   +1 more source

Metabolomic systems biology of trypanosomes [PDF]

, 2010
Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental ...
Barrett, M.P., Michael P. Barrett, Breitling, Rainer, Breitling, R., Breitling, Rainer,, Bakker, Barbara M.; id_orcid, Rainer Breitling, Barbara M. Bakker, Barrett, Michael P., Bakker, Barbara M.,, Bakker, B.M., Barrett, Michael P.,, Bakker, Barbara M.   +12 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source