Results 51 to 60 of about 91,527 (300)

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
core   +1 more source

MS2CNN: predicting MS/MS spectrum based on protein sequence using deep convolutional neural networks

BMC Genomics, 2019
Background Tandem mass spectrometry allows biologists to identify and quantify protein samples in the form of digested peptide sequences. When performing peptide identification, spectral library search is more sensitive than traditional database search ...
Yang-Ming Lin, Ching-Tai Chen, Jia-Ming Chang   +2 more
doaj   +1 more source

Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine

Molecules, 2020
Bacterial transglutaminase was used to label human plasma proteins with fluorescent tags. Protein lysines were modified with dansyl-epsilon-aminohexyl-Gln-Gln-Ile-Val-OH (dansylQQIV), while protein glutamines were modified with dansyl cadaverine. Labeled
Lawrence M. Schopfer, Oksana Lockridge
doaj   +1 more source

SLoMo: automated site localization of modifications from ETD/ECD mass spectra [PDF]

, 2009
Recently, software has become available to automate localization of phosphorylation sites from CID data and to assign associated confidence scores. We present an algorithm, SLoMo (Site Localization of Modifications), which extends this capability to ETD ...
Bailey, Christopher M, Cooper, Helen J., Cunningham, Debbie L, Heath, John K, Sweet, Steve M M, Zeller, Martin   +5 more
core   +1 more source

Multistage Detection of Tetrodotoxin Traces in Diodon hystrix Collected in El Salvador

Toxins, 2023
This study describes a multistage methodology to detect minute amounts of tetrodotoxin in fishes, a plan that may be broadened to include other marine organisms. This methodology was applied to porcupinefish (Diodon hystrix) collected in Punta Chiquirín,
Juan Carlos Fuentes-Monteverde, Marvin J. Núñez, Oscar Amaya-Monterosa, Morena L. Martínez, Jaime Rodríguez, Carlos Jiménez   +5 more
doaj   +1 more source

Pharmacoproteomic characterisation of human colon and rectal cancer [PDF]

, 2017
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge.
Domingo, Enric, Feller, Stephan M, Frejno, Martin, Heinzlmeir, Stephanie, Jarzab, Anna, Jesinghaus, Moritz, Johnstone, Elaine, Kerr, David, Klaeger, Susan, Knapp, Stefan, Koch, Heiner, Kramer, Karl, Kuster, Bernhard, Meng, Chen, Ruprecht, Benjamin, Slotta-Huspenina, Julia, Weichert, Wilko, Wilhelm, Mathias, Zenezini Chiozzi, Riccardo, Zheng, Runsheng   +19 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Subnanogram proteomics: impact of LC column selection, MS instrumentation and data analysis strategy on proteome coverage for trace samples [PDF]

, 2018
One of the greatest challenges for mass spectrometry (MS)-based proteomics is the limited ability to analyze small samples. Here we investigate the relative contributions of liquid chromatography (LC), MS instrumentation and data analysis methods with ...
Kelly, Ryan T., Lim, Sujung, Moore, Ronald J., Orphan, Victoria J., Paša-Tolić, Ljiljana, Piehowski, Paul D., Qian, Wei-Jun, Smith, Richard D., Zhao, Rui, Zhu, Ying   +9 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Comparative study on phytosterol oxidation products determination in high oleic sunflower oil by using cholesterol oxidation products or purified phytosterol oxidation products as reference materials

Journal of Agriculture and Food Research
Phytosterols received great interest over the last decade due to their capacity to compete with cholesterol absorption during digestion. However, phytosterols can be oxidized resulting in oxidation products (phytosterol oxidation products, POPs), which ...
Ambra Bonciolini, Annalisa Vissio, Raffaele Calaminici, Emanuele Forte, Vladimiro Cardenia   +4 more
doaj   +1 more source