Results 101 to 110 of about 6,793 (233)

Development and Validation of A Prognostic Nomogram to Guide Decision-making 
in Lung Large Cell Neuroendocrine Carcinoma

Chinese Journal of Lung Cancer, 2023
Background and objective Lung large cell neuroendocrine carcinoma (LCNEC) is a rare and highly malignant lung tumor with a poor prognosis. Currently, most research on LCNEC is based on retrospective studies and lacks validation in the real world.
Sheng CHEN, Shaoxiang LI, Zipeng WANG, Wenxi ZHANG, Liang ZHOU, Wenjie JIAO   +5 more
doaj   +1 more source

Persistent lineage plasticity driving lung cancer development and progression

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
Lineage imbalance among tumour‐initiating cell types persists after oncogenic transformation and, in the context of clinical intervention and the accumulation of multiple genomic alterations, ultimately culminates in histologic transformation. Abstract Background Lung cancer, a leading cause of cancer death, displays profound histologic and molecular ...
Fanchen Meng, Jianyu Li, Zhijun Xia, Qinglin Wang, Qinhong Sun, Siwei Wang, Lin Xu, Rong Yin   +7 more
wiley   +1 more source

Mushroom Bioactive Molecules as Anticancerous Agents: An Overview

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This review discusses the molecular mechanisms through which these compounds inhibit cancer progression, including the induction of reactive oxygen species, inhibition of mitotic kinase and angiogenesis, and suppression of topoisomerase activity. By providing the latest insights on these anti‐tumor agents and their pharmacological actions, our review ...
Ali Ikram, Nasir A. Ibrahim, Muhammad Tayyab Arshad, Abroo Fatima, Ali Asghar Taseer, Mahreen Faqeer Hussain, Zunair Abdullah, Nosiba S. Basher, Muhammed Adem Abdullahi, Ammar AL‐Farga, Mohammed Ali Al‐Duais   +10 more
wiley   +1 more source

Suitability of Frozen Pleural Fluid Pellets for Next‐Generation Sequencing‐Based Driver Gene Testing in Non‐Small Cell Lung Cancer

Thoracic Cancer, Volume 16, Issue 11, June 2025.
This study demonstrated a high success rate of driver gene testing using the Oncomine Dx Target Test (ODxTT) on fresh‐frozen pleural fluid pellets from patients with NSCLC. ABSTRACT Background Driver gene alterations are increasingly being identified, and multiplex genetic tests have become essential for determining the optimal treatment method for ...
Kazuki Nakashima, Kohei Otsubo, Yuko Tsuchiya‐Kawano, Hironori Mikumo, Eiji Iwama, Eiji Harada, Isamu Okamoto   +6 more
wiley   +1 more source

Immune Checkpoint Inhibitors in Large Cell Neuroendocrine Carcinoma: Current Status [PDF]

, 2018
Introduction: Large cell neuroendocrine carcinomas (LCNEC) are a group of rare high grade neuroendocrine tumors that often behave clinically like small cell carcinoma (SCLC) and are treated as such.
Anthony, Lowell B., Arnold, Susanne, Chauhan, Aman, Evers, B. Mark, Kolesar, Jill M., Thomas, Hala Elnakat   +5 more
core   +2 more sources

Large-cell neuroendocrine carcinoma (LCNEC) without pulmonary symptoms diagnosed in a cutaneous metastasis.

The American journal of case reports, 2014
Female, 60 FINAL DIAGNOSIS: Large-cell neuroendocrine carcinoma Symptoms: Back pain Medication: - Clinical Procedure: Vertebroplasty Specialty: Oncology.Unusual clinical course.An atypical presentation of large-cell neuroendocrine carcinoma was diagnosed from a metastatic nodule on the chest wall.The patient was a 60-year-old female who presented with ...
Yuan, Cai, Keating, Benjamin, Farricielli, Laurie A., Zhang, Kuixing   +3 more
openaire   +2 more sources

Artificial intelligence–driven microsatellite instability profiling reveals distinctive genetic features in patients with lung cancer

Cancer, Volume 131, Issue 9, 1 May 2025.
Abstract Background Microsatellite instability (MSI) has emerged as a predictive biomarker for immunotherapy response in various cancers, but its role in non–small cell lung cancer (NSCLC) is not fully understood. Methods The authors used the bioinformatics tool MIAmS to assess microsatellite status from next‐generation sequencing (NGS) data using a ...
Quentin Dominique Thomas, Julie Adèle Vendrell, Lakhdar Khellaf, Sarah Cavaillon, Xavier Quantin, Jérôme Solassol, Simon Cabello‐Aguilar   +6 more
wiley   +1 more source

Clinicopathologic features treatment prognosis and prognostic factors of neuroendocrine carcinoma of the endometrium: a retrospective analysis of 42 cases from the Kansai Clinical Oncology Group/Intergroup study in Japan [PDF]

, 2019
journal ...
0000003944, Fujimoto Etsuko, Futagami Masayuki, Ito Kimihiko, Kai Kentaro, Kuji Shiho, Matsumoto Harunobu, Mori Taisuke, Motohashi Takashi, Nagano Hiroaki, Nakagawa Satoshi, Nasu Kaei, Nishikawa Ryutaro, SHIKAMA Ayumi, Shimada Muneaki, Shimokawa Mototsugu, Shiozaki Takaya, Sugino Norihiro, Tasaki Kazuto, Teramoto Norihiro, Tokunaga Hideki, Tsuruta Tomohiko, Yamada Takashi, Yamada Yuki, Yano Mitsutake, Yoshioka Norihito   +25 more
core   +1 more source

Association of Baseline Serum Uric Acid With Venous Thromboembolism and Clinical Outcomes in Patients With Non‐Small Cell Lung Cancer

Thoracic Cancer, Volume 16, Issue 9, May 2025.
This prospective study of 626 patients with NSCLC identified baseline serum uric acid (SUA ≥ 310 μmol/L) as an independent predictor of venous thromboembolism (VTE; incidence: 19.1% vs. 7.9%, p < 0.001; SHR = 2.83, p < 0.001). Elevated SUA also correlated with reduced disease‐free survival in early‐stage (I–IIIA) patients (adjusted HR = 1.95, p = 0.018)
Xue‐Li Zhang, Chen Zhang, Lu Lang, Jia‐Wen Yi, Min Zhu, Yu‐Hui Zhang   +5 more
wiley   +1 more source

First-line selpercatinib for a patient with RET fusion-positive pulmonary large cell neuroendocrine carcinoma

Respiratory Medicine Case Reports
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an uncommon variant of non-small cell lung cancer (NSCLC), known for its aggressive behavior.
Tatsuru Eihuku, Seiichi Miwa, Tomoko Oshima, Hisano Ohba, Masahiro Shirai   +4 more
doaj   +1 more source