Results 221 to 230 of about 20,068,597 (246)

GPR55 Inhibits Inflammatory Factor TNF-α-Mediated RhoA/ROCK2/IκBα/p65 Signaling Pathway to Alleviate Diabetic Cardiomyopathy in Rats. [PDF]

Int J Gen Med
Wang J, Yang X, Gao X, Li D, Yao Z.
europepmc   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Strongly Anisotropic and Rapid Excitons Transport in Organic Crystal

Advanced Science, EarlyView.
The increased exciton diffusion length is beneficial to simplify device design and enhance photoelectric conversion efficiency. But the isotropic exciton diffusion may lead to reduced transport efficiency directed to the charge separation site. Here we have successfully achieved strongly anisotropic and rapid excitons transport in thienopyrrole ...
Minjie Li, Zheng‐Fei Liu, Jiajia Ma, Dayujia Huo, Ganglong Cui, Qing‐Zheng Yang, Yan Wan   +6 more
wiley   +1 more source

VPS35 Regulates Microglial Lipid Droplet Accumulation in Parkinson's Disease via Rab7. [PDF]

Glia
Liang Y, Chang T, Yan L, Li J, Zhang Y, Ding J, Fang Y, Hu G.   +7 more
europepmc   +1 more source

The impact of endocrine disrupting chemicals diethylstilbestrol and ketoconazole on lipid storage in in vitro matured bovine cumulus-oocyte complexes†. [PDF]

Biol Reprod
Asimaki K, Lest van de CHA, Wubbolts R, Jansen JWA, Helms JB, Aardema H, Duursen van MBM, Gadella BM.   +7 more
europepmc   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Image-Domain GAN Denoising for Sn100 kVp Ultra-Low-Dose Chest CT: A Retrospective Paired Image-Quality Study. [PDF]

Diagnostics (Basel)
Yao K, Lv L, Jiang X, Li Y, Zhang G, Li W, Zheng Y, Zhang Z, Zhang Z, Li X, Lv F.   +10 more
europepmc   +1 more source

Electron‐Beam Enables Spatially Resolved Defect‐Mediated Work Function Modulation in FAPbI3 Perovskite Thin Films

Advanced Science, EarlyView.
Electron‐beam irradiation enables defect‐mediated work function modulation in metal halide perovskites by regulating interstitial iodides. This approach allows continuous Fermi‐level tuning and spatially resolved formation of lateral surface‐potential‐defined junctions with built‐in potential.
Hyeonho Park, Seung‐Gu Choi, Jae‐Hwan Kim, Dong‐Jun Lee, Sung‐Kwang Jung, Gwanghee Lee, HongSeok Kim, Kyung‐Hwan Jin, Jin‐Wook Lee, Seong Heon Kim   +9 more
wiley   +1 more source