Results 81 to 90 of about 19,221,852 (336)

Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]

, 2017
The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached, Fish, Lisa, Goodarzi, Hani, Najafabadi, Hamed S   +3 more
core   +3 more sources

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source

Secondary cell-mediated lympholysis: importance of H-2 LD and SD factors

Journal of Experimental Medicine, 1976
Lymphocytes stimulated in mixed leukocyte cultures and left for 13-17 days, i.e. beyond their peak proliferative and cytotoxic reactivities, can be restimulated to give a secondary-type rapid and strong proliferative and cytotoxic response when ...
B. Alter, C. Grillot‐Courvalin, M. Bach, K. Zier, P. Sondel, F. Bach   +5 more
semanticscholar   +1 more source

Intelligent data analysis approaches to churn as a business problem: a survey [PDF]

, 2017
Globalization processes and market deregulation policies are rapidly changing the competitive environments of many economic sectors. The appearance of new competitors and technologies leads to an increase in competition and, with it, a growing ...
García Gómez, David, Nebot Castells, M. Àngela, Vellido Alcacena, Alfredo   +2 more
core   +2 more sources

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

Domain Specific Placebo Response in the Modified Friedreich's Ataxia Rating Scale

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The placebo response in clinical trials in ataxias complicates outcome interpretation and potentially obscures genuine treatment effects. We analyzed placebo group data from past trials in Friedreich Ataxia and observed notable responses in appendicular items, in contrast to minimal changes in axial function, as measured by respective ...
Christian Rummey, Jennifer M. Farmer, David R. Lynch   +2 more
wiley   +1 more source

Crystallization by microwave energy: Effects on the survival probability of lithia-based glass ceramics [PDF]

Brazilian Oral Research
This study evaluated the survival probabilities of two lithia-based glass-ceramics after final crystallization in a microwave furnace using conventional crystallization as a reference.
Pedro Santos DIAMANTINO, Camila da Silva RODRIGUES, Ana Beatriz Gomes de CARVALHO, João Paulo Mendes TRIBST, Hilton RIQUIERI, Nathália de Carvalho RAMOS, Diogo Miguel da Costa Cabecinha Pacheco VIEGAS, Edmara Tatiely Pedroso BERGAMO, Estevam Augusto BONFANTE, Guilherme de Siqueira Ferreira Anzaloni SAAVEDRA   +9 more
doaj   +1 more source

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema

EMBO Molecular Medicine
Secondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD.
Justine Creff, Asalaa Lamaa, Emeline Benuzzi, Elisa Balzan, Francoise Pujol, Tangra Draia-Nicolau, Manon Nougué, Lena Verdu, Florent Morfoisse, Eric Lacazette, Philippe Valet, Benoit Chaput, Fabian Gross, Regis Gayon, Pascale Bouillé, Julie Malloizel-Delaunay, Alessandra Bura-Rivière, Anne-Catherine Prats, Barbara Garmy-Susini   +18 more
doaj   +1 more source