Results 71 to 80 of about 20,068,597 (246)
White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram +3 more
wiley +1 more source
Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema
EMBO Molecular MedicineSecondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD.
Justine Creff +18 more
doaj +1 more source
Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the treatment effect of anticoagulation versus antiplatelet therapy in patients ...
Elena Badillo Goicoechea +53 more
wiley +1 more source
, 2019 (a) RI map processing and analysis strategy. (b) RI map of HeLa cells just before (t = 0 hours) or 3 hours after (t = 3 hours) loading with OA. (c) Time series of HeLa cells 2D RI maps, overlay of LD segmentations, and individual LD objects after ...
Mathieu Frechin (8156598) +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Inherited ataxias are clinically diverse neurodegenerative diseases, complicating the choice of outcome measures for trials. In spinocerebellar ataxia (SCA), regulatory concerns about the Scale for the Assessment and Rating of Ataxia (SARA) caused a shift toward functional SARA (f‐SARA), contributing to pivotal trial failure.
Christian Rummey +52 more
wiley +1 more source
Organ-specific clocks show phase differences under constant environmental conditions and LD cycles.
, 2019 (A) Schematic depicting the experimental conditions used. Seedlings were grown for 4 d under LD cycles and imaged either under constant light (LD-to-LL) or LD (LD-to-LD). The white triangle represents the beginning of imaging.
Anthony J. W. Hall (7251242) +4 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Blood‐based biomarkers are increasingly used to identify Alzheimer's disease (AD) pathology and may play an important role in early disease screening and participant selection for clinical trials. However, their performance across stages of cognitive impairment remains unclear. This study examined whether plasma biomarkers differ in
Maryam Abdolmaleki +7 more
wiley +1 more source
Crystallization by microwave energy: Effects on the survival probability of lithia-based glass ceramics [PDF]
Brazilian Oral ResearchThis study evaluated the survival probabilities of two lithia-based glass-ceramics after final crystallization in a microwave furnace using conventional crystallization as a reference.
Pedro Santos DIAMANTINO +9 more
doaj +1 more source
Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)
Arthritis Care &Research, EarlyView.Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram +25 more
wiley +1 more source
Diurnal locomotor activity from turbot in LD-LL-LD lighting conditions.
, 2019 Recording activity during 18 days is represented by double plot of two consecutive days and represented by actograms (A, D). The white and black bars above the actograms indicate light and dark periods.
Nicholas S. Foulkes (109671) +6 more
core +1 more source