Results 51 to 60 of about 14,804,559 (252)

AMČR - dokument C-LD-000011797 [PDF]

, 1997
Stav: 3Označení: LD000011797.tif (M. Gojda)Popis: Lokalita Podlusky 1.Poznámka: Dokument byl původně přiřazen k lokalitě C-L9000500 (Přestavlky u Roudnice nad Labem 1). Po sloučení lokalit C-L9000856 a C-L9000500 (19. 5.
https://api.aiscr.cz/id/OS-005864, https://api.aiscr.cz/id/ORG-000094   +1 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Proteome-level assessment of origin, prevalence and function of Leucine-Aspartic Acid (LD) motifs. [PDF]

, 2018
MOTIVATION:Leucine-aspartic acid (LD) motifs are short linear interaction motifs (SLiMs) that link paxillin family proteins to factors controlling cell adhesion, motility and survival.
Gao, Xin, Alam, Tanvir, Astro, Veronica, Canlas, Christian G, Momin, Afaque Ahmad Imtiyaz, Ali, Amal J., Adamo, Antonio, Alazmi, Meshari, Jaremko, Mariusz, Huser, Franceline, Naser, Rayan Mohammad Mahmoud, Huser, Raphaël, Jaremko, Lukasz, Merzaban, Jasmeen, Bajic, Vladimir B., Arold, Stefan T., Hong, Seungbeom, Walkiewicz, Katarzyna Wiktoria   +17 more
core   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Difficulties in Dagnosing Second Lanugage Learners with LD [PDF]

, 2010
This paper focuses on difficulties in diagnosing second language learners with LD (Learning Disabilities). The total number of foreigners studying Japanese grows yearly.
3369, 黒崎, 佐仁子, クロサキ, サトコ   +2 more
core   +2 more sources

Toxicity and Lethal Effect of Greenhouse Insecticides on Coccinella septempunctata (Coleoptera: Coccinellidae) as Biological Control Agent of Myzus persicae (Hemiptera: Aphididae)

Toxics, 2023
Deltamethrin and imidacloprid are commonly used insecticides for controlling sub-sucking insects in greenhouses. However, their application may cause sublethal effects on the aphid coccinellid predator Coccinella septempunctata (Coleoptera: Coccinellidae)
Panagiotis J. Skouras, Eirini Karanastasi, Ioannis Lycoskoufis, Vasilis Demopoulos, Anastasios I. Darras, Athanasios Tsafouros, Polina C. Tsalgatidou, John T. Margaritopoulos, George J. Stathas   +8 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Sex Is the Main Determinant of Levodopa Clinical Pharmacokinetics: Evidence from a Large Series of Levodopa Therapeutic Monitoring

Journal of Parkinson’s Disease, 2022
Background: Different studies, mostly with limited cohorts, have suggested the effects of patients’ characteristics on levodopa (LD) pharmacokinetics. Objective: We primarily aimed at investigating in a large population the relationship between patients’
Manuela Contin, Giovanna Lopane, Laura M.B. Belotti, Margherita Galletti, Pietro Cortelli, Giovanna Calandra-Buonaura   +5 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

LD-SKAIP クラウドデータの特性に関する研究 [PDF]

, 2022
【特集：LD-SKAIPによる学習の評価と支援】資料departmental bulletin ...
オガサワラ, サトシ, 小笠原, 哲史, 1444, 1443, Ogasawara, Satoshi   +4 more
core