Results 41 to 50 of about 20,068,597 (246)

Sex Is the Main Determinant of Levodopa Clinical Pharmacokinetics: Evidence from a Large Series of Levodopa Therapeutic Monitoring

Journal of Parkinson’s Disease, 2022
Background: Different studies, mostly with limited cohorts, have suggested the effects of patients’ characteristics on levodopa (LD) pharmacokinetics. Objective: We primarily aimed at investigating in a large population the relationship between patients’
Manuela Contin, Giovanna Lopane, Laura M.B. Belotti, Margherita Galletti, Pietro Cortelli, Giovanna Calandra-Buonaura   +5 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Linkage disequilibrium (LD), excluding singleton polymorphisms.

, 2012
Series refer to the observed LD for each major chromosome arm, and the expected LD from neutral equilibrium simulations for X-linked and autosomal loci, as given in panel A. (A) Average r2 for a series of SNP pair distance bins.
John E. Pool (108804), Russell B. Corbett-Detig (108808), Charis M. Cardeno (108818), Perot Saelao (108831), J. J. Emerson (108827), Kristian A. Stevens (108814), Marc W. Crepeau (108821), Charles H. Langley (108839), Ryuichi P. Sugino (108811), David J. Begun (108835), Pablo Duchen (108824)   +10 more
core   +1 more source

Improving the pedagogical expressiveness of IMS LD

, 2009
The IMS Learning Design specification (LD) was introduced in order to describe any learning and teaching scenario in a formal way. Its high level of generality, however, may make it difficult for teachers and instructional designers to apply it to their ...
Gilbert, Lester, Sitthisak, Onjira
core   +1 more source

A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin® Skin Nutrients Advanced A

Clinical, Cosmetic and Investigational Dermatology, 2014
Lawrence D Goldberg, Corina CryslerShaft Medical San Diego, San Diego, CA, USABackground: Superoxide dismutase (SOD) reduces the reactive oxygen species formation associated with oxidative stress.
Goldberg LD, Crysler C
doaj  

Genome-wide divergence and linkage disequilibrium analyses for Capsicum baccatum revealed by genome-anchored single nucleotide polymorphisms

Frontiers in Plant Science, 2016
Principal component analysis (PCA) with 36,621 polymorphic genome-anchored single nucleotide polymorphisms (SNPs) identified collectively for Capsicum annuum and Capsicum baccatum was used to show the distribution of these 2 important incompatible ...
Padma Nimmakayala, Venkata Lakshmi Abburi, Thangasamy Saminathan, Aldo Almeida, Brittany Davenport, Joshua Davidson, Chandra Mohan Reddy, Gerald Hankins, Andreas Ebert, Doil Choi, John Stommel, Umesh K Reddy   +11 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A High Cattle-Grazing Density Alters Circadian Rhythmicity of Temperature, Heart Rate, and Activity as Measured by Implantable Bio-Loggers

Frontiers in Physiology, 2021
Six cows managed under extensive grazing conditions were used to study the effect of moving the animals to a higher grazing density on the circadian rhythms of temperature (T), heart rate (HR), and activity (ACT), which were recorded by implantable bio ...
Carlos Palacios, Javier Plaza, José-Alfonso Abecia   +2 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Sustainable Approach for Linz-Donawitz Slag Waste as a Replacement of Cement in Concrete: Mechanical, Microstructural, and Durability Properties

Advances in Civil Engineering, 2020
Linz-Donawitz (LD) slag, solid waste produced during steel manufacture in basic oxygen furnace, is difficult when it comes to handling and disposal and has very limited utilization.
Richa Palod, S. V. Deo, G. D. Ramtekkar
doaj   +1 more source