Results 61 to 70 of about 61,184 (249)

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

In Vivo and In Vitro Pharmacodynamics of Anthelmintic Medication Used in Sheep

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine, 2019
Our research aimed to evaluate the efficacy of anthelmintic treatments in sheep, as well as the resistance occurrence risk for the most commonly used substances. Anthelmintic medication efficacy was evaluated on 30 animals from a private farm, located in
Mihai CERNEA, Roxana FILIP, Raul CĂTANĂ, Laura CĂTANĂ   +3 more
doaj   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

Deep generative LDA

, 2020
Linear discriminant analysis (LDA) is a popular tool for classification and dimension reduction. Limited by its linear form and the underlying Gaussian assumption, however, LDA is not applicable in situations where the data distribution is complex. Recently, we proposed a discriminative normalization flow (DNF) model.
Cai, Yunqi, Wang, Dong
openaire   +2 more sources

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice

Advanced Science, EarlyView.
A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi, Shuang He, Chengyi Li, Hung Chan, Zhenfeng Liu, Bin Yang, Qing Li   +6 more
wiley   +1 more source

Forecasting Financial Distress for Shaping Public Policy: An Empirical Investigation

Acta Informatica Pragensia
Background: Prediction of financial distress has been made more accurate and reliable through machine learning methods. Financial stress affects the business corporate entity, society and the general economy.
Soumya Ranjan Sethi, Dushyant Ashok Mahadik   +1 more
doaj   +1 more source

Medicamentos Não Sujeitos a Receita Médica de Dispensa Exclusiva em Farmácia em Portugal: Uma Oportunidade de Acesso Sub-Aproveitada?

Acta Médica Portuguesa, 2016
Introdução: Em 2013 foi introduzida em Portugal a classificação quanto à dispensa de medicamentos não sujeitos a receita médica de dispensa exclusiva em farmácia, uma subclassificação dos medicamentos não sujeitos a receita médica.
Ana Paula Martins, Elizabete Gonçalves, Ana Marcelo, Sergio Vilão, José Aranda Silva   +4 more
doaj   +1 more source