Results 241 to 250 of about 315,541 (290)

Improving the removal of phosphate in secondary effluent of domestic wastewater treatment plant [PDF]

, 2017
Ashekuzzaman , S.M., Jiang, Jia-Qian
core   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Ligand‐Intercalated MOFs Enable Reaction‐Pathway Engineering in Biomass Electrooxidation via Steric and π‐Electronic Microenvironment Control

Angewandte Chemie, EarlyView.
Through ligand length and π‐electron density modulation, metal–organic frameworks (MOFs) improve mass transport and hydrogen atom transfer (HAT), thus improving biomass electrooxidation. ABSTRACT Controlling reaction pathways in electrocatalytic biomass upgrading remains challenging because mass transport, substrate adsorption, and elementary kinetics ...
Junjie Chen, Zhongyuan Guo, Jisheng Xie, Lipeng Tang, Shiyun Li, Yifan Bu, Cheng Peng, Mengyao Zhao, Linda Zhang, Jihan Zhou, Haichao Liu, Hao Li, Mufan Li   +12 more
wiley   +2 more sources

Reconstructing the ischemic osteogenic microenvironment through hierarchical scaffolds orchestrating Mg²⁺ signaling and neuropilin-1-mediated angiogenesis. [PDF]

Bioact Mater
Pei Z, Xu H, Zhao P, Wen Y, Zhang Z, Huang L, Wang M, Peng B, Wen L, Wen P, Sun F.   +10 more
europepmc   +1 more source

Polyfluoralkylierte zellpenetrierende Peptid‐Additive verbessern die intrazelluläre Proteinaufnahme durch eine anhaltende und monomere Lipidinteraktion

Angewandte Chemie, EarlyView.
Wir berichten, dass nicht‐zytotoxische, polyfluoralkylierte zellpenetrierende Peptide (CPPs) als CPP‐Additive die intrazelluläre Proteinaufnahme signifikant verbessern, indem sie die Membranverweildauer der CPP‐Additive erhöhen. Durch die Kombination von biophysikalischen Experimenten und Molekulardynamiksimulationen zeigen wir zudem, dass die ...
Sarah Hansen, Hana Zupan, Ferhat Mutlu, Jan Vincent V. Arafiles, Rubén Cruz, Palina Dubatouka, Kenichi Ataka, Martin Lehmann, Bettina G. Keller, Joachim Heberle, Christian P. R. Hackenberger   +10 more
wiley   +1 more source

Thermocatalytic Transformation of Nitriles Utilizing Pristine and Calcined ZnCr Layered Double Hydroxides for the Synthesis of Various Tetrazole- and Kynurenic Acid-Based Drug Candidates. [PDF]

ACS Omega
Alsoliman H, Szabados M, Bélteky P, Kónya Z, Szatmári I, Mészáros R.   +5 more
europepmc   +1 more source

A LDH-Based Supramolecular Photosensitizer-Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration. [PDF]

Adv Sci (Weinh)
Wang T, Bian Y, Hu T, Li M, Tan Y, Yang Y, Jian X, Weng X, Tan C, Liang R.   +9 more
europepmc   +1 more source

High‐Altitude Hypoxemia in Adults With Sickle Cell Disease (SCD)

American Journal of Hematology, EarlyView.
Mofiyin A. Obadina, Sherri Morris, Tara Alin, Barbara LeVarge, Jane A. Little   +4 more
wiley   +1 more source

Polyfluoroalkyl‐Tagged Cell‐Penetrating Peptide‐Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction

Angewandte Chemie International Edition, EarlyView.
We introduce cell‐penetrating peptides (CPPs) with polyfluoroalkyl‐tags that drastically enhance intracellular protein delivery by promoting membrane retention. Via the combination of live‐cell imaging, biophysical analysis, and computational simulations, we reveal how fluorous CPPs interact with membranes via monomeric interactions and dynamic tag ...
Sarah Hansen, Hana Zupan, Ferhat Mutlu, Jan Vincent V. Arafiles, Rubén Cruz, Palina Dubatouka, Kenichi Ataka, Martin Lehmann, Bettina G. Keller, Joachim Heberle, Christian P. R. Hackenberger   +10 more
wiley   +1 more source

Comparison of LDH activity and LDH-M to predict death in patients with acetaminophen-induced acute liver failure. [PDF]

EXCLI J
Bhadra D, Rule JA, Lee WM, McGill MR.
europepmc   +1 more source