Results 111 to 120 of about 19,123,678 (263)

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Towards an Open Architecture for LDL

, 1989
We extend LDL to allow programs to call external procedures and vice versa. This extension allows the modularization of LDL, since external predicates are equivalent to external procedures written in LDL.
Ravi Krishnamurthy, An Ldl, Danette Chimenti, Ruben Gamboa   +3 more
core  

PCSK9 Inhibitors: Is the Time Ripe for the “Fast Track” Use Independently on the LDL-C Baseline Values in Acute Coronary Syndrome? [PDF]

: The low-density lipoprotein cholesterol (LDL-C) lowering decreases the risk to develop major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS).
Bellis A., Trimarco B., Mauro C., Barbato E., Morisco C.   +4 more
core   +1 more source

Transformer‐Based PET/CT Fusion Enables Preoperative Prediction and Prognostic Stratification of Spread Through Air Spaces in Lung Adenocarcinoma

Advanced Science, EarlyView.
An eight‐stream 2.5D Transformer integrates complementary PET metabolic and CT morphologic information to estimate spread‐through‐air‐spaces risk before surgery in lung adenocarcinoma. The model generalizes across independent centers, while its continuous risk score independently stratifies progression‐free survival, supporting further prospective ...
Xin‐Yu Zhu, Meng Meng, Zhen‐Zhen Wang, Deng‐Lu Lu, Ya‐Min Wei, Xu‐Chang Mi, Xing‐Yu Mu, Wei Fu   +7 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

MC-sample1-LDL-AM

, 2017
Admixture Mapping results for LDL-cholesterol: Mexico City sample
Esteban J Parra (7852496), Parra, Esteban J   +1 more
core   +1 more source

Silicon Nitride Resistive Memories

Advanced Electronic Materials, EarlyView.
Amorphous SiNx is an attractive resistance switching material for ReRAM applications due to its physicochemical properties, such as humidity resistance, low oxygen diffusivity, and is used as a metal diffusion blocker. By modifying the ratio between N and Si atoms, the microstructure of the SiNx is affected, rendering it possible to change the ...
Alexandros‐Eleftherios Mavropoulis, Nikolaos Vasileiadis, Iosif‐Angelos Fyrigos, Emmanouil Stavroulakis, Caroline Bonafos, Pascal Normand, Georgios Ch. Sirakoulis, Panagiotis Dimitrakis   +7 more
wiley   +1 more source

An improved method for estimating low LDL-C based on the enhanced Sampson-NIH equation

Lipids in Health and Disease
Background The accurate measurement of Low-density lipoprotein cholesterol (LDL-C) is critical in the decision to utilize the new lipid-lowering therapies like PCSK9-inhibitors (PCSK9i) for high-risk cardiovascular disease patients that do not achieve ...
Tatiana C. Coverdell, Maureen Sampson, Rafael Zubirán, Anna Wolska, Leslie J. Donato, Jeff W. Meeusen, Allan S. Jaffe, Alan T. Remaley   +7 more
doaj   +1 more source

High lipoprotein(a) results in overestimation of BQ-based low-density lipoprotein-cholesterol measurement

Journal of Lipid Research
Most conventional low-density lipoprotein cholesterol (LDL-C) assays are standardized by the CDC reference procedure of beta-quantification (BQ) method, which involves density-based ultracentrifugation to separate very low-density lipoprotein (VLDL) and ...
Azusa Yamazaki, Yuna Hakii, Masumi Ai, Shuji Miyake, Junichiro Takahashi, Akira Yoshimoto, Takahiro Kameda, Naoya Ichimura, Shuji Tohda, Shinji Yokoyama, Ryunosuke Ohkawa   +10 more
doaj   +1 more source