Results 91 to 100 of about 19,123,678 (263)

Ox-LDL-mediated repletion of ATP6V₀d2-KD cholesterol levels restores PV volumes and impacts parasite multiplication.

, 2019
A. Intracellular cholesterol levels displayed by nonsilenced or ATP6V0d2-KD macrophages treated or not with 50 μg/ml of ox-LDL for 48 hours, showing that ox-LDL replenishes the ~40% lower cholesterol amount of ATP6V0d2-KD to levels comparable to ...
Luiza Campos Reis (6843587), Cristina Mary Orikaza (6843593), Hiro Goto (631335), Joyce Umbelino da Silva Yamamoto (6843605), Eduardo Milton Ramos-Sanchez (6843590), Erica Valadares de Castro Levatti (6843599), Fernando Real (185142), Cristian Cortez (130519), Renato Arruda Mortara (103561), Carina Carraro Pessoa (6843584), Ana Carolina Benites Badaró (6843602), Vânia D’Almeida (135394)   +11 more
core   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

A Bibliometric and Visual Analysis of Publications on Low-Density Lipoprotein Cholesterol Estimating Equations

Cumhuriyet Science Journal
The concentration of low-density lipoprotein cholesterol (LDL-C) is recognized as a crucial factor in cardiovascular health. This study aims to conduct a comprehensive bibliometric and visual analysis to provide a comprehensive review of current research
Serra İlayda Yerlitaş, Ahu Cephe, Necla Koçhan, Gözde Ertürk Zararsız, Halef Okan Dogan, Gökmen Zararsız, Serkan Bolat   +6 more
doaj   +1 more source

Fatty liver in men is associated with high serum levels of small, dense low-density lipoprotein cholesterol

Diabetology & Metabolic Syndrome, 2012
Aims Our study addressed potential associations between fatty liver and small, dense low-density lipoprotein cholesterol (sd-LDL-C) levels using a cross-sectional analysis. Methods We enrolled 476 male subjects.
Hosoyamada Kaori, Uto Hirofumi, Imamura Yasushi, Hiramine Yasunari, Toyokura Eriko, Hidaka Yoshihiro, Kuwahara Tomomi, Kusano Ken, Saito Kazuto, Oketani Makoto, Ido Akio, Tsubouchi Hirohito   +11 more
doaj   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Low LDL-C and High HDL-C Levels Are Associated with Elevated Serum Transaminases amongst Adults in the United States: A Cross-sectional Study [PDF]

, 2014
Background: Dyslipidemia, typically recognized as high serum triglyceride, high low-density lipoprotein cholesterol (LDL-C) or low high-density lipoprotein cholesterol (HDL-C) levels, are associated with nonalcoholic fatty liver disease (NAFLD). However,
Jiang, Zhenghui, Yusuke Tsugawa, Kenneth Mukamal (509754), Elliot Tapper (509755), Simon C Robson, Elliot Tapper, Zhenghui Gordon Jiang (509753), Simon C. Robson (301209), Kenneth Mukamal, Mukamal, Kenneth, Tsugawa, Yusuke, Robson, Simon, Jiang, Zhenghui Gordon, Tapper, Elliot, Robson, Simon C, Yusuke Tsugawa (509756), Zhenghui Gordon Jiang   +16 more
core   +2 more sources

Beyond Probiotics: Postbiotics for Healthy Aquaculture

Advanced Science, EarlyView.
This critical review assesses limitations of probiotics and proposes postbiotics, preparations of inanimate microorganisms and their metabolites, as a more stable, controlled, and biosafe formulation. Postbiotics offer significant advantages during industrial aquafeed production and storage. However, their practical implementation is currently hindered
Michael Leonidas Chikindas, Delin Xu, Igor V. Popov, Kayque Ordonho Carneiro, Nilufar Arashovna Elova, Gullola Amirovna Bekmurodova, Dildora Amindjanovna Amirsaidova, Astghik Pepoyan, Shakhlo Mirjamalovna Miralimova, Oleg V. Mitrokhin, Liubov S. Sichel, John Tagg, Svetoslav Dimitrov Todorov   +12 more
wiley   +1 more source

Non-HDL cholesterol and LDL cholesterol in the dyslipidemic classification in patients with nonalcoholic fatty liver disease

Lipids in Health and Disease, 2017
Background Low-density lipoprotein cholesterol (LDL-C) always underestimates the true cholesterol burden in patients with nonalcoholic fatty liver disease (NAFLD).
Tingting Du, Xingxing Sun, Xuefeng Yu
doaj   +1 more source

Otimização e aplicação da quantificação do colesterol da lipoproteína de baixa densidade pequena e densa (sd-LDL-C) [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.
Cavalcante, Luciana da Silveira
core