Results 71 to 80 of about 19,123,678 (263)

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Non-HDL-C in Conjunction to LDL-C is associated with Incidence of Chronic Coronary Syndrome in Clinical Settings

Magna Medika
Background: The biggest cause of death and a major contributor to disability globally is coroner's artery disease (CAD).  Chronic coronary syndrome (CCS) is a term that can be used to describe a wide variety of CAD clinical manifestations in clinical ...
Ni Made Elva Mayasari, Yanti Rosita, Sindy Olivia   +2 more
doaj   +1 more source

LDL-cholesterol to HDL-cholesterol ratio discordance with lipid parameters and carotid intima-media thickness: a cohort study in China

Lipids in Health and Disease, 2020
Background The discordance of the low-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio with alterative lipid parameters may explain the inconsistent association of CIMT with the LDL-C/HDL-C ratio.
Yanmei Lou, Xue Li, Liming Cao, Pei Qin, Jing Shi, Yanyan Zhang, Changyi Wang, Jianping Ma, Li Wang, Xiaolin Peng, Hongen Chen, Shan Xu, Fulan Hu, Yashuang Zhao, Ping Zhao   +14 more
doaj   +1 more source

The lack of association between different LDL‐C levels and oxidized LDL in patients with type 2 diabetes

Chronic Diseases and Translational Medicine, 2023
Background High concentrations of low‐density lipoprotein cholesterol (LDL‐C) have been a known risk factor for cardiovascular diseases. Also, the role of oxidized LDL (ox‐LDL) in forming atherosclerosis plaque has been proven.
Soghra Rabizadeh, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Maryamossadat  Omidvar Siahkalmahalleh, Amirhossein Yadegar, Fatemeh Mohammadi, Armin Rajab, Alireza Esteghamati, Manouchehr Nakhjavani   +8 more
doaj   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

THE RISK FACTORS ASSOCIATED WITH DIABETIC DYSLIPIDEMIA AND ANTHROPOMETRIC PARAMETERS LINKED WITH AND WITHOUT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS

Pakistan Armed Forces Medical Journal, 2020
Objective: To ascertain and identify risk determinants linked with and without dyslipidemia in type 2 diabetic patients. Study Design: Comparative cross-sectional study.
Zara Khalid Khan, Asifa Majeed, Amir Rashid   +2 more
doaj  

Bland Altman Plots comparing measured LDL-C to calculated LDL-C.

, 2022
Measured LDL-C to Friedewald formula (A) and measured LDL-C to Martin Hopkins formula (B).
Ngalulawa Kone (14259304), Siyabonga Khoza (14259307), Mogomotsi Dintshi (14259301)   +2 more
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

LDL-C/HDL-C Ratio Predicts Carotid Intima-Media Thickness Progression Better Than HDL-C or LDL-C Alone [PDF]

, 2011
High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are strong predictors of atherosclerosis. Statin-induced changes in the ratio of LDL-C to HDL-C (LDL-C/HDL-C) predicted atherosclerosis progression better than ...
Mika Enomoto, Yasuki Nanjo, Eishi Esaki, Yuji Hirai, Maki Otsuka, Kanako Yokoi, Akiko Kasahara, Eita Kumagai, Kuniko Yoshikawa, Eri Tsukagawa, Shun-Ichi Kumagae, Tsutomu Imaizumi, Hisashi Adachi, Ako Fukami, Kinuka Ogata, Kyoko Ohbu-Murayama, Akira Satoh   +16 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source