Results 31 to 40 of about 19,123,678 (263)
Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]
, 2010 OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.Rabbani, Naila, D. Zehnder, A. Ceriello, P. J. Thornalley, N. Rabbani, Zehnder, Daniel, Chittari, Madhu Varma, C. W. Bodmer, Bodmer, Charles W., Ceriello, Antonio, M. V. Chittari, Thornalley, Paul J. +11 morecore +1 more sourcePharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins [PDF]
, 2014 Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.Herrington, D.M., Postmus, Iris, Trompet, S., Ridker, P.M., O'Donnell, C.J. (Christopher J.), Ballantyne, C. (Christie), Liu, YM, Kastelein, JJP, Rivadeneira Ramirez, F. (Fernando), Pearson, Richard, Arnold, A.M. (Alice), O???donnell, Christopher J., Palmer, Colin N.A., Boerwinkle, E., Wei, W.-Q. (Wei-Qi), Barnes, M.R., Viswanathan, Ananth C., Potter, S.C. (Simon), Arnold, A.M., Caulfield, M. (Mark), Groop, L, Viswanathan, A.C. (Ananth), McKeigue, Paul M., Eiriksdottir, Gudny, Pirinen, M. (Matti), Palmer, Colin N. A., Barratt, BJ, Edkins, Sarah, Waller, Matthew, Smith, AV, Whitsel, E.A. (Eric), de Keyser, Catherine E., Buckley, BM, Arsenault, B.J. (Benoit J.), Whitsel, E.A., Hammond, Naomi, Sever, P, Franco Duran, OH, Liu, Y, Corvin, A. (Aiden), Palmer, CN, Barratt, B.J., Liu, Ching-Ti, Kastelein, J.J.P. (John), Groop, L., Macfadyen, JG, de Keyser, Toke, Zhou, Kaixin, Ford, I, Trompet, S. (Stella), Su, Zhan, Boerwinkle, Eric, Chu, A.Y., Sotoodehnia, Nona, Franco, O.H., Band, G. (Gavin), Wiggins, Kerri L., Eiriksdottir, G, O'Donnell, CJ, Chen, Y.-D. Ida, Boerwinkle, E, Uitterlinden, AG, Potter, Simon C., Heckbert, Susan R, Feng, Q. (Qiping), Hofman, A., Bis, JC, Krauss, Ronald M., Nickerson, D.A. (Deborah), Harris, T.B. (Tamara), Evans, DS, Palmer, C.N.A. (Colin), Blackburn, H. (Hannah), Stanton, A. (Alice), Wood, N.W. (Nicholas), Tardif, J-C, Wiggins, K.L. (Kerri), Johnson, A.D. (Andrew), Giulianini, F., Jukema, JW, Kritchevsky, S.B., Munroe, PB, Pierre Dubé, Marie, Cupples, L.A. (Adrienne), Blackwell, K.L. (Kimberly), Griffin, P., Keyser, C.E. de, Pirinen, Matti, Morris, A., Sattar, N, Rivadeneira, F, Griffin, P. (Paula), Shields, Denis C., Herrington, DM, Hellenthal, Garrett, Plomin, R. (Robert), Stafford, J.M. (Jeanette M.), Bellenguez, C??line, Betteridge, J, Shields, D.C., Widaa, S. (Sara), Stürmer, Til, Hitman, G, Wiggins, K.L., Bumpstead, Suzannah J., Hovingh, G.K., Neil, A. (Andrew), Tardif, J.-C. (Jean-Claude), Lumley, T., O'Brien, E. (Eoin), Munroe, P. (Patricia), ?, ?, de Craen, AJM, Liu, C-T, Wiggins, KL, Ford, Ian, De Craen, AJ, O’Donnell, Christopher J., Stafford, Jeanette M., Sotoodehnia, N. (Nona), McCarthy, MI, Bramon, E. (Elvira), Slagboom, PE, Casas, J.P. (Juan), Neil, Andrew, MacFadyen, J.G. (Jean G.), Shields, D.C. (Denis C.), Taylor, KD, Doney, A., Wei, Wei-Qi, Adrienne Cupples, L, Wilke, RA, Taylor, K.D., Strange, A. (Amy), Spencer, Chris C.A., McCann, O.T. (Owen), Morris, Andrew, Welcome Trust Case Control Consort, Postmus, D. (Douwe), Emilsson, V., Freeman, Colin, Launer, L.J., Guo, Xiuqing, Spencer, Chris C. A., Avery, C.L., Cupples, L.A., Rice, Kenneth, Krauss, RM, Gray, Emma, Chasman, Daniel I., Sever, P. (Peter), Caulfield, M.J., Li, G. (Guo), O'Brien, Eoin, Franco, OH, Gudnason, V. (Vilmundur), other, and, Sotoodehnia, N, Nickerson, D.A., Jayakumar, A. (Alagurevathi), Boekholdt, S.M., Chu, AY, Uitterlinden, Andr?? G., Wilke, R.A. (Russell A.), Doney, Alex; id_orcid, Li, XH, Sun, FG, Colhoun, HM, MacFadyen, J.G., Chasman, Daniel, Avery, CL, Rice, K., Betteridge, John, Carr, F, Durrington, P.N. (Paul), Ngwa, JS, Buckley, B.M., Post, Wendy, Deshmukh, H.A., Herrington, D.M. (David), Liu, C.-T. (Ching-Ti), Giulianini, F. (Franco), Munroe, Patricia B., Hammond, N. (Naomi), Uitterlinden, A.G. (André), Ahlqvist, E. (Emma), Ridker, PM, Jukema, J.W., Widaa, Sara, Betteridge, J., Duncanson, A. (Audrey), Ding, JZ (Jing Zhong), Adrienne Cupples, L., Sever, Peter, Poulter, N, Zhou, K. (Kaixin), Ballantyne, C.M., Matthijs Boekholdt, S., Carr, F., Liu, CT, Stott, D.J. (David. J.), Slagboom, P.E., Morris, A.D. (Andrew), Buckley, Brendan M., Mathew, C.G. (Christopher G.), Stanton, A, Gudnason, V, Li, Xiaohui, Shaw-Hawkins, S. (Sue), O???brien, Eoin, Ding, Jingzhong, Uitterlinden, André G., Cupples, LA, Nyberg, F, Mathew, Christopher G., Wellcome Trust Case Control Consortium, Warren, Helen R., Wei, WQ, Chu, A.Y. (Audrey), Warren, H.R., Stott, D.J., Smith, Albert V., Barratt, B.J. (Bryan J.), Westendorp, Rudi G. J., Vasan, Ramachandran S., Bramon, Elvira, Plomin, Robert, Nyberg, F. (Fredrik), Hellenthal, F.A., McCarthy, M.I., Tardif, Jean-Claude, Sawcer, S.J. (Stephen), Pierre Dub??, Marie, Chen, Y-DI, Munroe, P.B., Band, Gavin, Tardif, JC, Rotter, J.I., Post, W. (Wendy), Groop, L. (Leif), Wilke, R.A., Trompet, Stella, Psaty, B.M. (Bruce), Harris, TB, Casas, Juan P., Keyser, C.E. (Catherina Elisabeth) de, Stafford, JM, Deloukas, Panos, Li, X. (Xiaohui), Herrington, David M., Neil, A, Brown, Matthew, Ida Chen, Y.-D., Bellenguez, C. (Céline), Li, Guo, Barroso, Ines, Sun, F. (Fangui), McKeigue, P.M., Launer, Leonore J., Guo, XQ, Lumley, Thomas, Kastelein, John J. P., Chu, Audrey Y., Smith, Nicholas L., Smith, A.V. (Davey), Hofman, Albert, Donnelly, L.A. (Louise), Palmer, CNA, Barnes, M.J. (Michael), Doney, A, Tardif, J.C., Postmus, I, Shaw-Hawkins, S, de Craen, Anton J. M., Stricker, Bruno H., Poulter, N.R. (Neil), Stanton, A., Liddle, J. (Jennifer), Avery, Christy L., Vasan, R.S., Su, Z. (Zhan), Barroso, I.E. (Inês), Ding, J, Colhoun, H.M. (H.), Ngwa, Julius S., Ahlqvist, E, Corvin, Aiden, Rotter, J.I. (Jerome I.), Johnson, Andrew D., Rotter, JI, Ricketts, M. (Michelle), McCarthy, M.I. (Mark), Ahlqvist, Emma, Franco, O.H. (Oscar), Trembath, R.C. (Richard), Ballantyne, Christie M., Sotoodehnia, N., Psaty, Bruce M., Wei, W-Q, Carr, Fiona, Hitman, G.A. (Graham), Liu, C.T., Feng, Q, Barnes, Michael, Smith, N.L., Caulfield, Mark J., Westendorp, RGJ, MacFadyen, Jean G., Doney, Alex, Boekholdt, SM, Gudnason, V., Deshmukh, HA, Slagboom, P.E. (Eline), Boekholdt, S.M. (Matthijs), Freeman, C. (Colin), Neil, A., Stricker, Bruno, Barnes, Michael R., Liddle, Jennifer, Whittaker, Pamela, Bis, J.C. (Joshua), Ngwa, J.S., Chasman, D.I. (Daniel), Gwilliam, R. (Rhian), Durrington, Paul N., Hofman, Bert, Denny, J.C. (Joshua C.), Jukema, J. Wouter, Johnson, A.D., Trembath, Richard, Rautanen, A. (Anna), Liu, Y. (YongMei), Mathew, Christopher G.; id_orcid, Jankowski, J.A. (Janusz Antoni), Donnelly, LA, Gwilliam, Rhian, Palmer, C.N.A., Wood, Nicholas W., Dubé, MP, Heckbert, SR, Bellenguez, Céline, Sattar, Naveed, Giannoulatou, E. (Eleni), Stott, David J., Lumley, T, Franco, Oscar H., Durrington, P.N., Deshmukh, Harshal A., De Keyser, CE, Whitsel, EA, Ahlqvist, E., Waller, M. (Matthew), Smith, A.V., Uitterlinden, André, Heckbert, S.R. (Susan), Blackwell, Jenefer M., Kritchevsky, SB, Craen, A.J. (Anton) de, Mckeigue, P.M. (Paul), Chasman, DI, Bumpstead, S. (Suzannah), Dube, M.P., Boekholdt, S. Matthijs, Feng, QiPing, Guo, X.Q., Slagboom, P. Eline, Stuermer, T, Rivadeneira, Fernando, Brown, M.A. (Matthew), Stricker, B.H.Ch. (Bruno), Edkins, T. (Ted), Blackburn, Hannah, Eiriksdottir, G. (Gudny), Smith, N.L. (Nicholas), Bis, J.C., Ravindrarajah, Radhi, Harris, T.B., Smith, J.D. (Joshua D.), Rice, K.M. (Kenneth), Barnes, MR, Wilke, Russell A., Hitman, G., Feng, QP, McCann, Owen T., Ding, J.Z., Sawcer, Stephen J., Vukcevic, D. (Damjan), Jukema, J.W. (Jan Wouter), Wouter Jukema, J, Liu, Y.M., Hitman, Graham, Strange, Amy, Li, G, Hunt, S.E. (Sarah), Eline Slagboom, P., Ding, J. (Jingzhong), Langford, C. (Cordelia), St??rmer, Til, Langford, Cordelia, Stricker, B.H., Shaw-Hawkins, S., Kastelein, JJ, Donnelly, P. (Peter), Evans, Daniel S., Deshmukh, H. (Harshal), Betteridge, J. (John), Boerwinkle, E.A. (Eric), Eiriksdottir, G., Hovingh, G. Kees, Westendorp, R.G.J., Johnson, AD, Bis, Joshua C., McCarthy, Mark I., Denny, Joshua C., Dronov, Serge, Emilsson, V. (Valur), Harris, Tamara B., Li, X, Westendorp, R.G.J. (Rudi), Warren, HR, Giulianini, Franco, Guo, X. (Xiuqing), Emilsson, Valur, Heckbert, S.R., Weston, P. (Paul), Chen, Y.D.I., Kastelein, J.J.P., Launer, LJ (Lenore), Gudnason, Vilmundur, Dronov, S. (Serge), Post, W., Vasan, RS, Poulter, Neil, Chen, YDI, Uitterlinden, André; id_orcid, Sever, P., Rivadeneira, F., Liu, Yongmei, Stanton, Alice, Kastelein, John J.P., Sattar, N. (Naveed), Gillman, M. (Matthew), Craen, A.J.M. de, Donnelly, Peter, de Craen, Anton J.M., Shaw-Hawkins, Sue, Arsenault, BJ, Postmus, I., Durrington, PN, Griffin, P, Smith, Joshua D., Smith, JD, Rice, K, Dubé, G.P. (Gregory), Spencer, C.C.A. (Chris C.), Zhou, KX, Hovingh, G.K. (Kees), O’Brien, Eoin, Gillman, Matthew, Nickerson, DA, Arsenault, B.J., Donnelly, L.A., O'Donnell, C.J., Trembath, Richard C., Warren, H. (Helen), O'Brien, E., Hofman, A. (Albert), Denny, JC, Post, W, Sattar, N., Taylor, Kent D., Ford, I., Vukcevic, Damjan, Stürmer, T., Poulter, N., Caulfield, MJ, Guo, X, Weston, Paul, Whitsel, Eric A., Colhoun, Helen M., Donnelly, Louise A., Uitterlinden, A.G., Stott, DJ, Doney, A.S.F. (Alex), Rautanen, Anna, Buckley, B.M. (Brendan M.), Deshmukh, Harshal, Jankowski, Janusz, Colhoun, H.M., Ridker, P.M. (Paul), Nyberg, Fredrik, Vasan, R.S. (Ramachandran Srini), Dubé, Marie Pierre, Emilsson, V, Krauss, R.M. (Ronald), Feng, Q.P., Arnold, Alice M., Brown, Matthew A., Psaty, BM, Arsenault, Benoit J., Zhou, K, Whittaker, P. (Pamela), Westendorp, RG, Sun, Fangui, Chen, YD, Slagboom, PE (Eline), Smith, J.D., Kritchevsky, Stephen B., Consort, WTCC, Nickerson, Deborah A., Evans, D.S. (Daniel), Smith, NL, Chen, Y.-D.I. (Ida), Taylor, K.D. (Kent), Stafford, J.M., Psaty, B.M., Griffin, Paula, Giannoulatou, Eleni, Hofman, A, Carr, F. (Fiona), Nyberg, F., Lumley, T. (Thomas), Giulianini, F, Duncanson, Audrey, Launer, L.J. (Lenore), Markus, Hugh S., Hovingh, GK, Trompet, S, Stricker, BH, Li, X.H., Ballantyne, CM, Launer, LJ, Chasman, D.I., Li, G., Kees Hovingh, G., Markus, H.S. (Hugh), Evans, D.S., Morris, A, Sun, F, Krauss, R.M., McKeigue, PM, Wei, W.Q., Jayakumar, Alagurevathi, Groop, Leif, Rotter, Jerome I., Ricketts, Michelle, Kritchevsky, S.B. (Stephen), Gray, E. (Emma), Ravindrarajah, R. (Radhi), Shields, DC, Deloukas, P. (Panagiotis), Pearson, R. (Ruth), Sun, F.G., Zhou, K.X., Denny, J.C., Hunt, Sarah E., Barratt, Bryan J., Stürmer, T, Ridker, Paul M., O'Brien, E, Arnold, AM, Palmer, Colin N. A.; id_orcid, Vasan, Ramachandran S, Harris, Tamara B, McCarthy, Mark I, Uitterlinden, André G, Nyberg, Fredrik,, Whitsel, Eric A, Palmer, Colin NA, Warren, Helen R, Smith, Albert V, Stricker, Bruno H, MacFadyen, Jean G, Chu, Audrey Y, McKeigue, Paul M, Kastelein, John JP, Chasman, Daniel I, Denny, Joshua C, Wiggins, Kerri L, Ballantyne, Christie M, Launer, Leonore J, Avery, Christy L, Franco, Oscar H, de Craen, Anton J M, Rotter, Jerome I, Barnes, Michael R, Durrington, Paul N, Lund University., de Keyser, Catherine E, Kastelein, John J P, Colhoun, Helen M, Kees Hovingh, G, Ngwa, Julius S, Buckley, Brendan M, Johnson, Andrew D, Ahlqvist, Emma,, Stafford, Jeanette M, Munroe, Patricia B, Evans, Daniel S, Bis, Joshua C, Smith, Joshua D, Stott, David J, Deshmukh, Harshal A, Psaty, Bruce M, Westendorp, Rudi G J, Groop, Leif,, Donnelly, Louise A, Ida Chen, Y-D, Arnold, Alice M, Ridker, Paul M, Palmer, Colin N A, Smith, Nicholas L, Herrington, David M, Matthijs Boekholdt, S, Barratt, Bryan J, O'Donnell, Christopher J, O’Donnell, Christopher J, de Craen, Anton JM, Eline Slagboom, P, Kritchevsky, Stephen B, Shields, Denis C, Krauss, Ronald M, Nickerson, Deborah A, Westendorp, Rudi GJ, Arsenault, Benoit J, Caulfield, Mark J, Wilke, Russell A, Taylor, Kent D +627 morecore +2 more sourcesEfficacy and Safety of Alirocumab as Add-on Therapy in High–Cardiovascular-Risk Patients With Hypercholesterolemia Not Adequately Controlled With Atorvastatin (20 or 40 mg) or Rosuvastatin (10 or 20 mg)::Design and Rationale of the ODYSSEY OPTIONS Studies [PDF]
, 2014 The phase 3 ODYSSEY OPTIONS studies (OPTIONS I, NCT01730040; OPTIONS II, NCT01730053) are multicenter, multinational, randomized, double-blind, active-comparator, 24-week studies evaluating the efficacy and safety of alirocumab, a fully human monoclonal ...Peter H. Jones, Robinson, Jennifer G., Hanotin, Corinne, Du, Yunling, Jones, Peter H., Harold E. Bays, Corinne Hanotin, Yunling Du, Colhoun, Helen M., Donahue, Stephen, Jennifer G. Robinson, Helen M. Colhoun, Stephen Donahue, Bays, Harold E. +13 morecore +1 more sourceCirculating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes
Journal of Diabetes Research, 2015 Aims. To elucidate the levels of malondialdehyde-modified LDL (MDA-LDL)-related variables for predicting coronary artery stenosis (CAS) by coronary CT angiography (CCTA) in asymptomatic patients with type 2 diabetes (T2DM). Methods.Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hiroaki Yagyu, Hirohito Sone, Hitoshi Shimano +13 moredoaj +1 more sourceThe correlation between lipoprotein(a) and coronary atherosclerotic lesion is stronger than LDL-C, when LDL-C is less than 104 mg/dL
BMC Cardiovascular Disorders, 2021 Background Lp(a) and LDL-C are both risk factors of atherosclerotic cardiovascular disease (ASCVD). But there was a contradiction point in LDL-C and Lp(a) control.Chuang Li, Qiwen Chen, Mei Zhang, Yin Liu, Yushun Chu, Fanpeng Meng, Jianyu Wang, Jie Tang, Jian Luo, Xiulong Niu, Maoti Wei +10 moredoaj +1 more sourceIn silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic +6 morewiley +1 more source
