Results 51 to 60 of about 302,479 (284)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Association of medication adherence and depression with the control of low-density lipoprotein cholesterol and blood pressure in patients at high cardiovascular risk [PDF]

, 2019
Background: Many patients at high cardiovascular risk do not reach targets for low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP).
Böhm, Michael, Katzmann, Julius L., Laufs, Ulrich, Mahfoud, Felix, Schulz, Martin   +4 more
core   +1 more source

Evaluation of different formulas for LDL-C calculation [PDF]

Lipids in Health and Disease, 2010
Friedewald's formula for the estimation of LDL-C concentration is the most often used formula in clinical practice. A recent formula by Anandaraja and colleagues for LDL-C estimation still needs to be evaluated before it is extensively applied in diagnosis.
Vujović, Ana, Kotur-Stevuljević, Jelena, Spasić, Slavica, Bujisić, Nada, Martinović, Jelena, Vujović, Milica, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Pajić, Dragoljub   +8 more
openaire   +5 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene. [PDF]

, 2017
BACKGROUND AND AIMS: Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The repeat-one (R1) domain of AnxA2 binds to PCSK9, blocking its ability to promote degradation of low-density lipoprotein ...
Anastasia Z. Kalea, Anders Franco-Cereceda, Andrew Wong, Aroon Hingorani, Barbara J. Jefferis, Bernstein, Bharadwaj, Boardman-Pretty, Bresnick, Bulger, Cariou, Cartharius, Claudia Giambartolomei, Decker, Diana Kuh, Fairoozy, Gerke, Global Lipids Genetics C, Grewal, Grewal, Hedhli, J.P. Casas, Jackie Cooper, Jackie F. Price, Jon White, Kim, Ko, Kotowski, Kwon, Lang, Lasse Folkersen, Liu, Ly, Mayer, McDowell, Meena Kumari, Mika Kivimaki, Nassoury, Nikolaev, Peter Whincup, Pierce, Poirier, Rebecca Hardy, Reva, Roaa Hani Fairoozy, S. Goya Wannamethee, Seidah, Seidah, Spano, Stela McLachlan, Steve E. Humphries, Thomas Grewal, Tom R. Gaunt, Turley, Ward, Ward, Westra, Yoav Ben-Shlomo, Yusufzai, Zweig   +59 more
core   +5 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Non-invasive skin cholesterol testing: a potential proxy for LDL-C and apoB serum measurements

Lipids in Health and Disease, 2021
Background Lipid management is the first line of treatment for decreasing the incidence of cardiovascular events in patients with coronary heart disease (CHD), and a variety of indicators are used to evaluate lipid management.
Jiacheng Lai, Yongsheng Han, Chongjian Huang, Bin Li, Jingshu Ni, Meili Dong, Yikun Wang, Qingtong Wang   +7 more
doaj   +1 more source

Cost-Effectiveness of LDL-C Lowering With Evolocumab in Patients With High Cardiovascular Risk in the United States [PDF]

, 2016
Randomized trials have shown marked reductions in low-density lipoprotein cholesterol (LDL-C), a risk factor for cardiovascular disease (CVD), when evolocumab is administered.
Fonarow, G.C., Gandra, S.R., Lindgren, P., Lothgren, M., Somaratne, R., van Hout, B., Villa, G.   +6 more
core   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Improving the cost effectiveness equation of cascade testing for Familial Hypercholesterolaemia (FH) [PDF]

, 2015
Purpose of Review : Many International recommendations for the management of Familial Hypercholesterolaemia (FH) propose the use of Cascade Testing (CT) using the family mutation to unambiguously identify affected relatives.
Futema, M, Griffin, M, Humphries, SE, Pears, R   +3 more
core