Results 211 to 220 of about 1,208,067 (297)

The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials

British Journal of Nutrition, 2016
H. Ho, J. Sievenpiper, A. Zurbau, Sonia Blanco Mejia, E. Jovanovski, F. Au‐Yeung, A. Jenkins, V. Vuksan   +7 more
semanticscholar   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Machine learning-based identification of cardiovascular risk modifiers in patients with very high LDL cholesterol: A cross-sectional study. [PDF]

Medicine (Baltimore)
Karataş HÖ, Değer Ü, Söğütlügil SA, Gündoğdu A, Tazegül G, Fak AS.   +5 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Polygenic risk scores and LDL cholesterol: Improving precision in primary cardiovascular prevention. [PDF]

Am J Prev Cardiol
Rana JS, Shabani M.
europepmc   +1 more source

PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis.

Journal of Clinical Endocrinology and Metabolism, 2016
A. Langsted, B. Nordestgaard, M. Benn, A. Tybjærg-Hansen, P. Kamstrup   +4 more
semanticscholar   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Polygenic risk scores enhance LDL cholesterol-based risk stratification for coronary artery disease. [PDF]

Am J Prev Cardiol
Harper C, Misra A, Patel AP, Cho SM, Koyama S, Peloso GM, Hornsby W, Nakao T, Natarajan P.   +8 more
europepmc   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models. [PDF]

J Neurochem
Baumart GJ, Rodrigues MS, Sholl JN, de Sousa AC, Weber AF, Costa-Beber LC, Farias HR, Costa MV, Peres AM, de Camargo PR, Fróes FT, Bast RK, de Bem AF, Figueiró F, Guma FTCR, de Oliveira J.   +15 more
europepmc   +1 more source