Results 191 to 200 of about 604,324 (300)

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

Small Interfering RNA for LDL-Cholesterol Reduction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

JACC Adv
Batista F, Mamede I, Dacoregio M.
europepmc   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

LDL-cholesterol distance to target: A practical tool for guiding lipid-lowering treatment decisions. [PDF]

Atheroscler Plus
Palloni MC, Farella T, Faggiano A, Vatri M, Fattirolli F, Angelino E, Ambrosetti M, Ruscica M, Corsini A, Carugo S, Poli A, Faggiano P.   +11 more
europepmc   +1 more source

Liver Proteomic Alterations Induced by Chronic Fluoride Exposure in Type 2 Diabetic Mice: An Exploratory Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Water fluoridation is recognized as one of the major public health achievements of the 20th century due to its effectiveness in reducing dental caries. Recommended fluoride concentrations in drinking water (0.7–1.5 mgF/L) aim to maximize dental benefits while minimizing adverse effects.
Laura Ribeiro, Heloisa Aparecida Barbosa da Silva Pereira, Juliana Sanches Trevizol, Aislan Quintiliano Delgado, Aline Dionízio, Tamara Teodoro Araujo, Tânia Mary Cestari, José Roberto Bosqueiro, Marília Afonso Rabelo Buzalaf   +8 more
wiley   +1 more source

Progress in Achieving LDL Cholesterol Target Levels in a High-Risk Patient Population in Slovakia. [PDF]

Diagnostics (Basel)
Toth S, Olsavsky L, Fulop P, Dvoroznakova M, Sevcik M, Vanova N, Weis V.   +6 more
europepmc   +1 more source

Long‐Term Blood Pressure Variability, Hippocampal Subfield Volume and Cognitive Decline: A Population‐Based Prospective MRI Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Long‐term blood pressure variability (BPV) is associated with cognitive decline, yet the underlying mechanisms have not been fully elucidated. Purpose To investigate the associations between long‐term BPV and hippocampal subfield volume and cognitive function and to assess the mediation effect of hippocampal subfield volume.
Fei Li, Jing Chen, Huijing Shi, Ling Yang, Xianyu Zhu, Rui Li, Xinyu Zhao, Xiaoliang Liang, Shun Zhang, Yaping Zhang, Han Lv, Jing Li, Shuohua Chen, Yuntao Wu, Ying Hui, Shouling Wu, Zhenchang Wang, Xiaoshuai Li   +17 more
wiley   +1 more source

Comparative evaluation of LDL-cholesterol estimation using machine learning algorithms and conventional equations in a large middle eastern cohort. [PDF]

Clinics (Sao Paulo)
Ahmed FS, Ahmad MI, Begum M, Rao D, Joan S.   +4 more
europepmc   +1 more source

Association Between MRI‐Derived Right‐to‐Left Ventricular Volume Ratio and Regional Left Ventricular Myocardial Dysfunction in Patients With Pulmonary Arterial Hypertension

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Right ventricular (RV) to left ventricular (LV) end‐diastolic volume ratio (RV/LV) is a validated marker of RV dilation in pulmonary arterial hypertension (PAH), yet its impact on LV myocardial function and the underlying mediating pathway is incompletely characterized.
Han Fang, Yuan Li, Jin Wang, Wei‐Feng Yan, Ke Shi, Shi‐Qin Yu, Xue Li, Wen‐Rong Li, Jia‐Ke Li, Jing‐Yi Guo, Li Jiang, Zhi‐Gang Yang   +11 more
wiley   +1 more source

When Direct LDL Cholesterol Assays Fail: A Case Series of Analytically Implausible Results. [PDF]

Ann Lab Med
Park S, Yu J, Kim S, Lee W, Chun S.
europepmc   +1 more source