Results 101 to 110 of about 2,591,141 (428)

Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity.

Journal of Lipid Research, 1990
We have reported the use of a retroviral vector to introduce the low density lipoprotein (LDL) receptor gene into receptor-deficient Watanabe heritable hyperlipidemic (WHHL) rabbit fibroblasts (Miyanohara, A., M. F. Sharkey, D. Steinberg, J. L.
MF Sharkey, A Miyanohara, RL Elam, T Friedmann, JL Witztum   +4 more
doaj  

TabMixer: Excavating Label Distribution Learning with Small-scale Features [PDF]

arXiv, 2022
Label distribution learning (LDL) differs from multi-label learning which aims at representing the polysemy of instances by transforming single-label values into descriptive degrees. Unfortunately, the feature space of the label distribution dataset is affected by human factors and the inductive bias of the feature extractor causing uncertainty in the ...
arxiv  

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Evaluation of ABCA1 gene polymorphism as a prognostic index of fibrosis progression in NAFLD patients

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Dyslipidemias, hepatic steatosis index, and ABCA1 (rs1800977) gene polymorphism CC genotype; were the only independent predictors of advanced fibrosis in NAFLD‐patients. Abstract Introduction It had been evident that non‐alcoholic fatty liver disease (NAFLD) is the new era epidemic.
Samar E. Ghanem, Maha M. Elsabaawy, Mervat M. Abdelkareem, Marwa L. Helal, Warda Othman, Mahitab Elsayed, Dalia M. Elsabaawy, Ashraf El Fert   +7 more
wiley   +1 more source

Relative importance of the LDL receptor and scavenger receptor class B in the β-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages

Journal of Lipid Research, 2000
We investigated the mechanism of β-very low density lipoprotein (β-VLDL)-induced foam cell formation derived from peritoneal macrophages from control mice and low density lipoprotein (LDL) receptor-deficient mice to elucidate the role of the LDL receptor
Nicole Herijgers, Miranda Van Eck, Suzanne J.A. Korporaal, Peter M. Hoogerbrugge, Theo J.C. Van Berkel   +4 more
doaj  

Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice [PDF]

Journal of Lipid Research, 2001
The low density lipoprotein receptor (LDLR) plays a major role in regulation of plasma cholesterol levels as a ligand for apolipoprotein B-100 and apolipoprotein E (apoE). Consequently, LDLR-deficient mice fed a Western-type diet develop significant hypercholesterolemia and atherosclerosis.
Masa-aki Kawashiri, Daniel J. Rader, Ellen Puré, David C. Usher, Muredach P. Reilly, Yuzhen Zhang   +5 more
openaire   +4 more sources

Atherogenic effect of Arecoline: A computational study [PDF]

, 2012
There are over 600 million people worldwide covering Asian and Oceanic countries including India have the habit of chewing areca nut as masticator in different forms. Arecoline (C8H13NO2) has been reported as one of the abundant constituents of areca nut.
Chetia, Pankaj, Choudhury, Karabi Dutta, Choudhury, Manabendra Dutta, Datta-choudhari, Mohan, Talukdar, Anupam Das   +4 more
core   +2 more sources

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Mitogenic stimulation alters the regulation of LDL receptor gene expression in human lymphocytes.

Journal of Lipid Research, 1990
To address the possibility that influences other than ambient cholesterol concentrations regulate low density lipoprotein (LDL) receptor expression, the effect of mitogenic activation on the levels of LDL receptor mRNA in human lymphocytes was examined ...
JA Cuthbert, PE Lipsky
doaj  

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

Advanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu   +11 more
wiley   +1 more source