Results 131 to 140 of about 2,591,141 (428)

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals

AGING MEDICINE, EarlyView.
The prevalence of neurologically asymptomatic CSVD is common in the nondiabetic population. Glycated hemoglobin A1c correlated with periventricular white matter hyperintensities. Fasting blood glucose was associated with deep cerebral microbleeds. Better control of blood glucose may have a beneficial effect on reducing the risk of CSVD.
Xinxin Ma, Fang Liu, Lei Qiu, Juan Chen, Wei Du, Jing He, Aizhen Sheng, Yinhong Liu   +7 more
wiley   +1 more source

Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women

Journal of Lipid Research, 1997
Studies with animal models suggest that saturated fatty acids raise low density lipoprotein (LDL)-cholesterol levels by reducing LDL receptor-mediated clearance. To examine this directly in humans, we studied the effects of lowering dietary saturated fat
V A Mustad, T D Etherton, A D Cooper, A M Mastro, T A Pearson, S S Jonnalagadda, P M Kris-Etherton   +6 more
doaj  

Generation of Intracellular Signals by Low Density Lipoprotein Is Independent of the Classical LDL Receptor [PDF]

, 2017
Low density lipoprotein cholesterol (LDL) and apolipoprotein B-100 (1 to 15 μg/mL) had no significant influence on the inositol-1,4,5-trisphosphate (InsPa) formation in vascular smooth muscle cells and fibroblasts. Low density lipoprotein cholesterol (15
Locher, Rudolf, Sachinidis, Agapios, Vetter, Wilhelm   +2 more
core  

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K., Hageman, J., Herrema, H.J., Kuipers, F.   +3 more
core   +3 more sources

Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor−/− Mice

Circulation Research, 2011
Rationale: Human studies and mouse models have provided evidence for angiotensin II (Ang II)–based mechanisms as an underlying cause of aneurysms localized to the ascending aorta.
D. Rateri, Jessica J. Moorleghen, Anju Balakrishnan, A. P. Owens, Deborah A. Howatt, V. Subramanian, Aruna Poduri, R. Charnigo, L. Cassis, A. Daugherty   +9 more
semanticscholar   +1 more source

Gear‐Switch‐Integrated Dual‐Mode Three‐Wheeled Exoskeleton that Empowers Cyborg Insects with Enhanced Open‐Loop Locomotion Control Precision and Load Capacity

Advanced Intelligent Systems, EarlyView.
Cyborg insects’ low open‐loop control precision and limited sensor payload hinder applications. This article introduces an exoskeleton that improves motion precision and payload capacity. With a 7.2 cm × 14 cm size, it enhances load capacity to over 400 g and enables high‐precision movement without feedback control, expanding application scenarios for ...
Rui Li, Zezhong Zhang, Duc Long Le, Chen Lv, Sun Woh Lye, Hirotaka Sato   +5 more
wiley   +1 more source

Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor

Journal of Lipid Research, 2007
Factors that regulate apolipoprotein E (apoE) secretion by macrophages will have important effects on vessel wall lipid flux and atherosclerosis. Macrophages express the LDL receptor, which binds apoE with high affinity and could thereby affect the net ...
Danijela Lucic, Zhi Hua Huang, De Sheng Gu, Michael K. Altenburg, Nobuyo Maeda, Theodore Mazzone   +5 more
doaj  

Interleukin-6 blockade raises LDL via reduced catabolism rather than via increased synthesis: a cytokine-specific mechanism for cholesterol changes in rheumatoid arthritis [PDF]

, 2017
Objectives Patients with rheumatoid arthritis (RA) have reduced serum low-density lipoprotein cholesterol (LDL-c), which increases following therapeutic IL-6 blockade. We aimed to define the metabolic pathways underlying these lipid changes.
Caslake, Muriel, McCarey, David, McInnes, Iain, Packard, Chris J., Porter, Duncan, Robertson, Jamie, Sattar, Naveed   +6 more
core   +1 more source

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]

Journal of Lipid Research, 2011
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We have identified a fragment antigen-binding (Fab) 1D05 which binds PCSK9 with nanomolar affinity.
Y. Ni, S. Di Marco, J. Condra, L. Peterson, Weirong Wang, Fubao Wang, S. Pandit, Holly A. Hammond, R. Rosa, R. Cummings, Dana D. Wood, Xiaomei Liu, M. Bottomley, Xun Shen, R. Cubbon, Sheng-ping Wang, D. Johns, C. Volpari, Lora Hamuro, J. Chin, Lingyi Huang, J. Zhao, Salvatore Vitelli, Peter Haytko, D. Wisniewski, L. Mitnaul, C. Sparrow, B. Hubbard, A. Carfi, A. Sitlani   +29 more
semanticscholar   +1 more source