Results 151 to 160 of about 1,464,846 (295)

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet, Chenglong Yu, Cammie Tran, Sultana Monira Hussain, Chad A. Bousman, Mark R. Nelson, Andrew M. Tonkin, John J. McNeil, Paul Lacaze   +8 more
wiley   +1 more source

Associations of plasma level of soluble LDL receptor with cardiovascular events and mortality in a large prospective cohort study. [PDF]

Lipids Health Dis
Kim S, Jun HJ, Jo G, Park D, Kwak S, Shin MJ, Krauss RM.   +6 more
europepmc   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

LDL receptor-independent mechanisms of proprotein convertase subtilisin/kexin type 9 in cardiovascular pathophysiology. [PDF]

Front Cardiovasc Med
Su H, Guo X, Li Q, Yuan X, Wu X, Zhao Z, Kan Y, Yang Y, Fu Z, Qi Z, Song G.   +10 more
europepmc   +1 more source

Sailing the Uncharted Waters of Familial Hypercholesterolemia LDL Receptor Genetic-Related Variants: Land in Sight? [PDF]

JACC Basic Transl Sci, 2023
Santos RD.
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Cell type-specific control of cardiometabolic disease by the dileucine motif of the LDL receptor-related protein LRP1. [PDF]

J Biol Chem
Igel E, Jaeschke A, Haller A, Asman M, Mattam U, Alagarsamy J, Chella Krishnan K, Hui DY.   +7 more
europepmc   +1 more source

Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol. [PDF]

J Mol Med (Berl), 2023
Zegeye MM, Nakka SS, Andersson JSO, Söderberg S, Ljungberg LU, Kumawat AK, Sirsjö A.   +6 more
europepmc   +1 more source

Left ventricular function improvement during angiotensin receptor–neprilysin inhibitor treatment in a cohort of HFrEF/HFmrEF patients

ESC Heart Failure, Volume 12, Issue 2, Page 1151-1165, April 2025.
Prediction of LVEF improvement in patients with HFrEF and HFmrEF following treatment with Sacubitril/Valsartan. Workflow of this study investigating the functional capacity improvement in response to Sacubitrail/Valsartsan in a real‐world scenario of heart failure treatment.
Florian Appenzeller, Tobias Harm, Manuel Sigle, Parwez Aidery, Klaus‐Peter Kreisselmeier, Livia Baas, Andreas Goldschmied, Meinrad Paul Gawaz, Karin Anne Lydia Müller   +8 more
wiley   +1 more source

LDL receptor-mediated lipoprotein uptake fuels human CD4+ T cell polarization toward a c-MAF/IL-10- and FOXP3-driven phenotype. [PDF]

JCI Insight
Markovska A, van Heusden NS, Duijzer D, Bodelón A, Rogani G, Mocholi E, Stigter EC, Gulersonmez C, Kooijman S, Van der Zee L, Mulder MT, Roeters van Lennep JE, Rensen PC, van Loosdregt J, Vastert SJ, Zelcer N, Boes M, Schipper HS.   +17 more
europepmc   +1 more source