Results 151 to 160 of about 131,908 (260)

Western Diet Combined With Chemical Induction: A Strategy for Rapid Development of MASLD Pathology in Mice

iNew Medicine, EarlyView.
ABSTRACT Objective The molecular mechanisms underlying the development of metabolic‐dysfunction‐associated steatotic liver disease (MASLD) are essential for developing appropriate treatments. The purpose of this study was to establish an MASLD model in mice with rapid and consistent progression.
Ting‐Ting Chen, Nan Li, Shuo Wang, Miao Sun, Rui Yang, Shi‐Hao Zhang, Xiao‐Lei Li, Chen Dong, Ke‐Yuan Chen, Wu‐Yi Sun, Na Zhou   +10 more
wiley   +1 more source

LDL receptor-mediated endocytosis of <i>Escherichia coli</i> α-hemolysin mediates renal epithelial toxicity. [PDF]

Proc Natl Acad Sci U S A
Kuhn HW, Smither MR, Jin RJ, Collins CA, Ma H, Sina J, Gaut JP, Diamond MS, Hunstad DA.   +8 more
europepmc   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Evaluation of glycemic status and subclinical atherosclerosis in familial hypercholesterolemia subjects with or without LDL receptor mutation. [PDF]

Cardiovasc Diabetol
Di Giacomo Barbagallo F, Bosco G, Di Marco M, Scilletta S, Miano N, Musmeci M, Martedì M, González-Lleó AM, Ibarretxe D, De Francesco EM, Malaguarnera R, Di Pino A, Masana L, Purrello F, Piro S, Scicali R.   +15 more
europepmc   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Sphingosine 1-phosphate receptor 1signaling in macrophages reduces atherosclerosis in LDL receptor-deficient mice. [PDF]

JCI Insight
Potì F, Scalera E, Feuerborn R, Fischer J, Arndt L, Varga G, Pardali E, Seidl MD, Fobker M, Liebisch G, Hesse B, Lukasz AH, Rossaint J, Kehrel BE, Rosenbauer F, Renné T, Christoffersen C, Simoni M, Burkhardt R, Nofer JR.   +19 more
europepmc   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

The LDL receptor-related protein 1 (LRP1) facilitates ACE2-mediated endocytosis of SARS-CoV2 spike protein-containing pseudovirions. [PDF]

J Biol Chem
Wani MM, Cooper JM, Migliorini M, Strickland DK.   +3 more
europepmc   +1 more source

Serum Apelin‐13 and Galectin‐3 in COVID‐19: Associations With Routine Biochemical Parameters and Diagnostic Performance in a Case–Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
Serum Apelin‐13 and Galectin‐3 levels were measured by ELISA in COVID‐19–positive patients and controls and evaluated alongside routine biochemical parameters. COVID‐19 patients showed significant alterations in liver, renal, inflammatory, and metabolic markers.
İsmail Uğurlu
wiley   +1 more source

Atorvastatin enhances LDL receptor-mediated LDL-C uptake and modulates PCSK9 protein expression in pancreatic β-cells. [PDF]

Islets
Zhang Z, Zheng H, Zhang L, Su P, Chen X, Xiang A, Yang J, Guan H, Fan J, Yu Q.   +9 more
europepmc   +1 more source