Results 231 to 240 of about 2,527,752 (315)

Efficacy and safety of low‐dose atorvastatin plus ezetimibe for primary hypercholesterolemia: A randomized, double‐blind, multicenter phase 3 trial

Lipids, EarlyView.
Low‐dose atorvastatin combined with ezetimibe achieves superior LDL‐C reduction (44.8%) compared with equivalent or higher‐dose statin monotherapy in Korean patients, presenting a more effective and safer therapeutic strategy potentially applicable to broader Asian populations.
Tae Oh Kim, Kyounghoon Lee, Jin‐Man Cho, Hyuck‐Jun Yoon, Tae‐Ho Park, Jung Hyun Choi, Jung‐Won Suh, Seok‐Yeon Kim, Hong‐Seok Lim, Jong‐Seon Park, Deok‐Kyu Cho, Gyung‐Min Park, Sung‐Gyun Ahn, Sanghoon Shin, Sung Uk Kwon, Dae‐Hyeok Kim, Sang‐Rok Lee, Jung‐Hoon Sung, Hwan‐Cheol Park, Seung‐Whan Lee   +19 more
wiley   +1 more source

Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice

, 1995
Rajendra K. Tangirala, Edward M. Rubin, Wulf Palinski   +2 more
openalex   +1 more source

Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats

Lipids, EarlyView.
Abstract Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined the effects of exogenous phytosterol (PS) and OPS on growth parameters and lipid metabolism in rats.
Tomonari Koyama, Kyoichi Osada
wiley   +1 more source

Immunization of LDL Receptor–Deficient Mice With Homologous Malondialdehyde-Modified and Native LDL Reduces Progression of Atherosclerosis by Mechanisms Other Than Induction of High Titers of Antibodies to Oxidative Neoepitopes

, 1998
Stefan Freigang, Sohvi Hörkkö, Elizabeth R. Miller, Joseph L. Witztum, Wulf Palinski   +4 more
openalex   +1 more source

Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults–A Double‐Blind Trial

Molecular Nutrition &Food Research, EarlyView.
This study explored how a 90‐day nutraceutical blend with prebiotics, minerals, and silymarin affects the gut‐brain axis in overweight adults. Results showed improved gut microbiota, reduced inflammation, and better sleep, mood, and quality of life, suggesting a strong link between gut health and mental well‐being.
Aline Boveto Santamarina, Victor Nehmi Filho, Jéssica Alves de Freitas, Lucas Augusto Moysés Franco, Roberta Cristina Martins, Joyce Vanessa Fonseca, José Antônio Orellana Turri, Mariana Tedesco Hufnagel, Daniel Pecoraro Demarque, Bruna Fernanda Rio Branco da Silva, Arianne Fagotti Gusmão, Eloísa Helena Ribeiro Olivieri, Erica de Souza, Esther Alves de Souza, José Pinhata Otoch, Ana Flávia Marçal Pessoa   +15 more
wiley   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At‐Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers

Molecular Nutrition &Food Research, EarlyView.
Yerba mate intake shows cardiometabolic beneficial effects decreasing blood pressure, blood lipids, inflammatory biomarkers and body fat in healthy and hypercholesterolemic non‐habitual consumers. ABSTRACT Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties.
Laura Bravo, Sara Martínez‐López, Jose Luis Sierra‐Cinos, Raquel Mateos, Beatriz Sarriá   +4 more
wiley   +1 more source

Preventive Effect of Upland Pigmented Potatoes Against LPS‐Induced Inflammation in THP‐1 Macrophages

Molecular Nutrition &Food Research, EarlyView.
The anti‐inflammatory activity of extracts from three commercial potato varieties cultivated upland was investigated on THP‐1 macrophages insulted with LPS. While the chlorogenic acid (CGA)‐rich extract from Kennebec reduced inflammation only at supraphysiological doses, carotenoid‐rich Desirèe and anthocyanin (ACN)‐rich Bleuet decreased TNF‐α, IL‐1β ...
Marta Toccaceli, Alessandra Marinelli, Federico Ballabio, Laura Bassolino, Roberto Lo Scalzo, Bruno Parisi, Daniela Pacifico, Federica Nicoletti, Carlo Camilloni, Giuseppe Mandolino, Katia Petroni   +10 more
wiley   +1 more source

Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis

Molecular Nutrition &Food Research, EarlyView.
Resveratrol and pterostilbene reduced the steatotic status of animals fed a high‐fat, high‐sucrose diet, involving differential and specific mechanisms of action for each stilbene. Thus, changes in riboflavin metabolism, nicotinamide mononucleotide metabolism, or in the LysoPC(18:1)‐mediated effects contribute to the specific actions of pterostilbene ...
Alfredo Fernández‐Quintela, Emily P. Laveriano‐Santos, Tania Portolés, Andreu Gual‐Grau, Juan Vicente Sancho, Maria P. Portillo   +5 more
wiley   +1 more source

Oral Delivery of Ellagic Acid Encapsulated in Milk Exosomes: Sex‐Based Differences in Bioavailability, Urolithin Production, and Gut Microbiota Modulation

Molecular Nutrition &Food Research, EarlyView.
Sex‐dependent effects on plasma metabolome and gut microbiota were observed after oral administration of ellagic acid (EA) encapsulated in milk‐derived exosomes (EXO‐EA) versus non‐encapsulated EA (NEA) and non‐loaded EXOs. EXO‐EA impacted plasma metabolome, modulated gut microbiota, and increased urolithin A and SCFA production sex‐dependently ...
María Ángeles Ávila‐Gálvez, María Romo‐Vaquero, Carmen Mazarío‐Gárgoles, Joao Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, María Victoria Selma, Antonio González‐Sarrías, Juan Carlos Espín   +8 more
wiley   +1 more source