Results 211 to 220 of about 131,908 (260)
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LDL Receptor's β-Propeller Displaces LDL
Science, 2002The low density lipoprotein receptor (LDLR) binds to lipoprotein extracellularly and releases it in the endosome. In his Perspective, Innerarity discusses new structural work (Rudenkoet al.) that shows that an interdomain interaction that occurs at low pH likely displaces ligand from the receptor in the endosome.
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Expression of LDL receptor and uptake of LDL in mouse preimplantation embryos
Molecular and Cellular Endocrinology, 2003The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos.The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched blastocyst stage were analyzed by RT-PCR and nested PCR ...
N, Sato +7 more
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Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm
Atherosclerosis, 2000The level of LDL in plasma is the major determinantof the risk of vascular disease and lowering the level ofLDL diminishes that risk, both in those with and thosewithout symptomatic vascular disease [1–4]. Fully un-derstanding the factors that govern the concentration ofplasma LDL is, therefore, one of our most importantchallenges.
A D, Sniderman, X J, Zhang, K, Cianflone
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1998
Recently we described the specific inhibitory action of lactoferrin on chylomicron remnant (CR) uptake into the intact rat liver. Injection of lactoferrin but not transferrin (7 mg/100 g animal weight) together with radiolabelled CR inhibits in vivo uptake into liver by 50%. No inhibition of uptake into spleen was observed1.
M. Huettinger +3 more
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Recently we described the specific inhibitory action of lactoferrin on chylomicron remnant (CR) uptake into the intact rat liver. Injection of lactoferrin but not transferrin (7 mg/100 g animal weight) together with radiolabelled CR inhibits in vivo uptake into liver by 50%. No inhibition of uptake into spleen was observed1.
M. Huettinger +3 more
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Regulation of LDL Receptors in vivo
1984The information reviewed here indicates that LDL receptor activity in vivo is regulated in normal animals and probably in normal humans. Furthermore, LDL receptor activity is also regulated in patients with heterozygous Familial Hypercholesterolemia. Our experiments in patients with this disease indicate that one can exploit the normal regulation of ...
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Orvosi hetilap, 2003
The members of the LDL receptor family are structurally related endocytic receptors. Our view on these receptors has considerably changed in recent years. Not only have new members of the family been identified, but also several interesting observations have been published concerning the biological function of these molecules.
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The members of the LDL receptor family are structurally related endocytic receptors. Our view on these receptors has considerably changed in recent years. Not only have new members of the family been identified, but also several interesting observations have been published concerning the biological function of these molecules.
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Nihon rinsho. Japanese journal of clinical medicine, 2000
The LDL receptor family is known to bind and internalize apoE-rich lipoproteins, and thought to play a role in lipoprotein metabolism. The recently identified new members showed the structural heterogeneity in the family, and molecular biological approach using animal models revealed the essential biological function in neural development.
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The LDL receptor family is known to bind and internalize apoE-rich lipoproteins, and thought to play a role in lipoprotein metabolism. The recently identified new members showed the structural heterogeneity in the family, and molecular biological approach using animal models revealed the essential biological function in neural development.
openaire +1 more source