Results 201 to 210 of about 1,464,846 (295)

LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy. [PDF]

Nat Commun
Wang N, Merits A, Veit M, Lello LS, Kong S, Jiao H, Chen J, Wang Y, Dobrikov G, Rey FA, Su S.   +10 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Gene expression patterns of the LDL receptor and its inhibitor Pcsk9 in the adult zebrafish brain suggest a possible role in neurogenesis. [PDF]

Eur J Neurosci
Gence L, Morello E, Rastegar S, Apalama ML, Meilhac O, Bascands JL, Diotel N.   +6 more
europepmc   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor. [PDF]

Cell Death Dis
Chen J, Hu J, Guo X, Yang Y, Qin D, Tang X, Huang Z, Wang F, Hu D, Peng D, Yu B.   +10 more
europepmc   +1 more source

Machine Learning–Based Comparative Analysis of Blood Cell–Derived Inflammatory Indices for Predicting MAFLD and Liver Fibrosis: Evidence From NHANES 2017–2020

Journal of Clinical Laboratory Analysis, EarlyView.
This research assesses the correlations and diagnostic efficacy of blood cell‐derived inflammatory indicators in predicting metabolic dysfunction‐associated fatty liver disease (MAFLD) and liver fibrosis using NHANES 2017–2020 data. AISI had the highest predictive capability for MAFLD, while PLR served as the most efficacious indicator for fibrosis ...
Hao Chen, Qinmei Chen, Xiangqian Wang, Yixian He, Xiqiao Zhou   +4 more
wiley   +1 more source

Lectin-type oxidized LDL receptor-1 as a potential therapeutic target for cerebral cavernous malformations treatment. [PDF]

Front Neurosci
Ashok K, Martinez T, Sesen J, Nasim S, Lang SS, Heuer G, Tucker A, Lopez-Ramirez MA, Smith ER, Ghalali A.   +9 more
europepmc   +1 more source

Long‐Term Blood Pressure Variability, Hippocampal Subfield Volume and Cognitive Decline: A Population‐Based Prospective MRI Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Long‐term blood pressure variability (BPV) is associated with cognitive decline, yet the underlying mechanisms have not been fully elucidated. Purpose To investigate the associations between long‐term BPV and hippocampal subfield volume and cognitive function and to assess the mediation effect of hippocampal subfield volume.
Fei Li, Jing Chen, Huijing Shi, Ling Yang, Xianyu Zhu, Rui Li, Xinyu Zhao, Xiaoliang Liang, Shun Zhang, Yaping Zhang, Han Lv, Jing Li, Shuohua Chen, Yuntao Wu, Ying Hui, Shouling Wu, Zhenchang Wang, Xiaoshuai Li   +17 more
wiley   +1 more source

Ferritin-based disruptor nanoparticles: A novel strategy to enhance LDL cholesterol clearance via multivalent inhibition of PCSK9-LDL receptor interaction. [PDF]

Protein Sci
Incocciati A, Cappelletti C, Masciarelli S, Liccardo F, Piacentini R, Giorgi A, Bertuccini L, De Berardis B, Fazi F, Boffi A, Bonamore A, Macone A.   +11 more
europepmc   +1 more source