Results 241 to 250 of about 2,527,752 (315)

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

Molecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez, Antonio Vico‐Padilla, Claus Schneider, Juan Carlos Espín, Antonio González‐Sarrías, Juan Antonio Giménez‐Bastida   +5 more
wiley   +1 more source

Photoperiod‐Dependent Effects of Phenolic‐Enriched Fruit Extracts on Postprandial Triacylglyceride Levels and Acute Inflammatory Responses in F344 Rats

Molecular Nutrition &Food Research, EarlyView.
This study investigates the photoperiod‐dependent effects of eight phenolic‐rich fruit extracts on postprandial blood triacylglyceride (TAG) levels and serum inflammatory markers in F344 rats, following an oral lipid tolerance test (OLTT) and a lipopolysaccharide (LPS)‐induced inflammatory challenge. Results showed that cherry and plum extracts reduced
Francesca Manocchio, Diego Morales, Èlia Navarro‐Masip, Gerard Aragones, Cristina Torres‐Fuentes, Francisca Isabel Bravo, Begoña Muguerza   +6 more
wiley   +1 more source

Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Changes the Composition of the Oral, But Not the Intestinal Microbiome

Molecular Nutrition &Food Research, EarlyView.
This randomized, double‐blind, and placebo‐controlled crossover study investigated the effects of an increased intake of inorganic nitrate from beetroot juice over 4 weeks on the oral and intestinal microbial communities in older adults with treated high blood pressure.
Rebeka Fejes, Joana Séneca, Petra Pjevac, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Romy Steiner, Karl‐Heinz Wagner, Richard J. Woodman, Catherine P. Bondonno, Jonathan M. Hodgson, David Berry, Michael Wolzt, Oliver Neubauer   +13 more
wiley   +1 more source

Exploring the Impact of a High‐Fat Diet on Brain Homeostasis: A Comprehensive Analysis of the Absence of Inflammation

Molecular Nutrition &Food Research, EarlyView.
Male and female mice were fed different diets for up to 24 weeks to study the effects of phytosterols (PS) on weight gain and brain immune cells. PS reduced weight gain in HFD‐fed mice. Microglia were isolated from brains and analyzed, revealing no diet‐driven inflammation changes, but differences based on sex and age.
Laura Plantera, Kerstin Immig, Anne‐Kristin Fritsche, Madlen Reinicke, Alon Zemer, Alon Monsonego, Uta Ceglarek, Ingo Bechmann   +7 more
wiley   +1 more source

Effect of unprocessed red meat on obesity and related factors: A systematic review and meta‐analysis

Obesity, EarlyView.
Abstract Objective The objective of this study was to conduct a systematic review and meta‐analysis of intervention trials that have determined the effect of unprocessed red meat (URM) intake on obesity‐related outcomes. Methods The populations, interventions, controls, and outcomes (PICO) framework was used to create questions to search seven ...
Md Akheruzzaman, Marleigh Hefner, Daniel Baller, Shane Clark, Zahra Feizy, Diana M. Thomas, Nikhil V. Dhurandhar   +6 more
wiley   +1 more source

Early‐Onset Obesity and Tirzepatide Treatment: A Post Hoc Analysis of the SURMOUNT Clinical Trials

Obesity, EarlyView.
In the phase 3 SURMOUNT clinical trial program for obesity, substantial body weight reductions were observed with tirzepatide treatment. This post hoc analysis evaluated baseline characteristics of participants with early‐onset obesity (diagnosed before age 25) and changes in body weight and cardiometabolic markers by age of obesity onset.
Evgenia Gourgari, Gitanjali Srivastava, Aaron S. Kelly, Donna Mojdami, Dachuang Cao, Madhumita A. Murphy, Chrisanthi A. Karanikas, Clare J. Lee   +7 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Cholesterol in LDL receptor recycling and degradation.

Clinica Chimica Acta, 2019
The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum (ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol response element binding protein 2 (SREBP2), pro-protein convertase subtilisin/kexin type 9 (PCSK9) and inducible degrader of LDLR (IDOL).
Hui-xian Yang, Min Zhang, Shi-yin Long, Q. Tuo, Ying Tian, Jian‐Xiong Chen, Cai-ping Zhang, D. Liao   +7 more
semanticscholar   +4 more sources

Lowering LDL cholesterol, but not raising LDL receptor activity, by ezetimibe [PDF]

Journal of Clinical Lipidology, 2013
Ezetimibe, an inhibitor of intestinal cholesterol absorption, is effective in lowering serum low-density lipoprotein (LDL) cholesterol with or without coadministration of statin. Ezetimibe-plus-statin therapy enhances LDL receptor activity, but it is still unclear whether ezetimibe alone enhances LDL receptor activity, resulting in LDL cholesterol ...
Mitsunobu Kawamura, Hiroshi Hayashi
openaire   +2 more sources

LDL Receptor's β-Propeller Displaces LDL [PDF]

Science, 2002
The low density lipoprotein receptor (LDLR) binds to lipoprotein extracellularly and releases it in the endosome. In his Perspective, Innerarity discusses new structural work (Rudenkoet al.) that shows that an interdomain interaction that occurs at low pH likely displaces ligand from the receptor in the endosome.
openaire   +1 more source

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

Annual Review of Cell Biology, 1985
PATHWAYS OF RECEPTOR-MEDIATED ENDOCYTOSIS 3 Entry Into Coated Pits 3 Intracellular Routes ...
J. Goldstein, M. Brown, R. G. Anderson, D. Russell, W. Schneider   +4 more
semanticscholar   +1 more source