Results 261 to 270 of about 140,038 (304)
Some of the next articles are maybe not open access.
Revue medicale de Bruxelles, 1991
The low density lipoprotein receptor removes the cholesterol-carrying lipoproteins from blood. When the activity of LDL receptors is reduced, as a result of genetic or acquired abnormalities, LDL increases in blood, resulting in atherosclerosis. Heterozygote familial hypercholesterolemia (one mutant gene) is characterized by a 50% reduction of LDL ...
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The low density lipoprotein receptor removes the cholesterol-carrying lipoproteins from blood. When the activity of LDL receptors is reduced, as a result of genetic or acquired abnormalities, LDL increases in blood, resulting in atherosclerosis. Heterozygote familial hypercholesterolemia (one mutant gene) is characterized by a 50% reduction of LDL ...
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Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm
Atherosclerosis, 2000The level of LDL in plasma is the major determinantof the risk of vascular disease and lowering the level ofLDL diminishes that risk, both in those with and thosewithout symptomatic vascular disease [1–4]. Fully un-derstanding the factors that govern the concentration ofplasma LDL is, therefore, one of our most importantchallenges.
A D, Sniderman, X J, Zhang, K, Cianflone
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Solution Structure of the Sixth LDL-A Module of the LDL Receptor,
Biochemistry, 2000The low-density lipoprotein receptor (LDLR) is the primary mechanism for uptake of plasma cholesterol into cells and serves as a prototype for an entire class of cell surface receptors. The amino-terminal domain of the receptor consists of seven LDL-A modules; the third through the seventh modules all contribute to the binding of low-density ...
C L, North, S C, Blacklow
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Lowering LDL cholesterol, but not raising LDL receptor activity, by ezetimibe
Journal of Clinical Lipidology, 2013Ezetimibe, an inhibitor of intestinal cholesterol absorption, is effective in lowering serum low-density lipoprotein (LDL) cholesterol with or without coadministration of statin. Ezetimibe-plus-statin therapy enhances LDL receptor activity, but it is still unclear whether ezetimibe alone enhances LDL receptor activity, resulting in LDL cholesterol ...
Hiroshi, Hayashi, Mitsunobu, Kawamura
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Regulation of LDL Receptors in vivo
1984The information reviewed here indicates that LDL receptor activity in vivo is regulated in normal animals and probably in normal humans. Furthermore, LDL receptor activity is also regulated in patients with heterozygous Familial Hypercholesterolemia. Our experiments in patients with this disease indicate that one can exploit the normal regulation of ...
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1998
Recently we described the specific inhibitory action of lactoferrin on chylomicron remnant (CR) uptake into the intact rat liver. Injection of lactoferrin but not transferrin (7 mg/100 g animal weight) together with radiolabelled CR inhibits in vivo uptake into liver by 50%. No inhibition of uptake into spleen was observed1.
M. Huettinger +3 more
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Recently we described the specific inhibitory action of lactoferrin on chylomicron remnant (CR) uptake into the intact rat liver. Injection of lactoferrin but not transferrin (7 mg/100 g animal weight) together with radiolabelled CR inhibits in vivo uptake into liver by 50%. No inhibition of uptake into spleen was observed1.
M. Huettinger +3 more
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Orvosi hetilap, 2003
The members of the LDL receptor family are structurally related endocytic receptors. Our view on these receptors has considerably changed in recent years. Not only have new members of the family been identified, but also several interesting observations have been published concerning the biological function of these molecules.
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The members of the LDL receptor family are structurally related endocytic receptors. Our view on these receptors has considerably changed in recent years. Not only have new members of the family been identified, but also several interesting observations have been published concerning the biological function of these molecules.
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Nihon rinsho. Japanese journal of clinical medicine, 2000
The LDL receptor family is known to bind and internalize apoE-rich lipoproteins, and thought to play a role in lipoprotein metabolism. The recently identified new members showed the structural heterogeneity in the family, and molecular biological approach using animal models revealed the essential biological function in neural development.
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The LDL receptor family is known to bind and internalize apoE-rich lipoproteins, and thought to play a role in lipoprotein metabolism. The recently identified new members showed the structural heterogeneity in the family, and molecular biological approach using animal models revealed the essential biological function in neural development.
openaire +1 more source