Results 281 to 290 of about 2,612,734 (405)

Genetic variation at a splicing branch point in intron 9 of the low density lipoprotein (LDL)-receptor gene: a rare mutation that disrupts mRNA splicing in a patient with familial hypercholesterolaemia and a common polymorphism [PDF]

, 1996
J. L. Webb
openalex   +1 more source

Age Estimation From Blood Test Results Using a Random Forest Model

Journal of Clinical Laboratory Analysis, EarlyView.
From the perspective of preventive medicine, it is essential to clarify the relationship between medical examination data and aging and health problems. We successfully and accurately estimated age from clinical examination data using a random forest model. Postmenopausal women tended to have higher age estimates than premenopausal women.
Satomi Kodera, Osamu Yokoi, Masaki Kaneko, Yuka Sato, Susumu Ito, Katsuhiko Hata   +5 more
wiley   +1 more source

Inhibition of a novel Dickkopf-1-LDL receptor-related proteins 5 and 6 axis prevents diabetic cardiomyopathy in mice. [PDF]

Eur Heart J
Ma E, Wo D, Chen J, Yan H, Zhou X, He J, Wu C, Wang Q, Zuo C, Li X, Li L, Meng Q, Zheng L, Peng L, Chen L, Peng J, Ren DN, Zhu W.   +17 more
europepmc   +1 more source

MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells. [PDF]

Int J Mol Sci, 2022
Pratt J, Haidara K, Annabi B.
europepmc   +1 more source

Comparison of Univariate and Multivariate Reference Interval Methods

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background In clinical practice, reference intervals play a pivotal role in interpreting laboratory test results. Yet, when several tests are taken into consideration simultaneously, the traditional univariate intervals might not suffice due to the elevated risk of Type 1 errors.
Esra Kutsal Mergen, Sevilay Karahan
wiley   +1 more source

Indication‐Specific Dosing and Dose‐Evaluation Strategies in New Indications for Non‐Oncology Monoclonal Antibodies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Compared to traditional small molecule drugs, monoclonal antibodies (mAbs) often display more complex pharmacokinetic (PK) and pharmacodynamic (PD) properties that may be impacted by disease‐specific factors. For mAbs in non‐oncology indications, where the same drug might be used for conditions involving different organ systems and/or having ...
Sherouk M. Tawfik, Fei Tang
wiley   +1 more source

Schisandrin A in Schisandra chinensis Upregulates the LDL Receptor by Inhibiting PCSK9 Protein Stabilization in Steatotic Model. [PDF]

J Microbiol Biotechnol
Kim HJ, Park SK, Park SH, Lee YG, Park JH, Hwang JT, Chung MY.   +6 more
europepmc   +1 more source

Pharmacokinetics and Safety of Fenofibrate in Participants with Mild Hepatic Impairment or with Advanced Fibrosis due to Metabolic‐Associated Fatty Liver Disease

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fenofibrate is contraindicated in patients with advanced hepatic fibrosis due to limited clinical data. We evaluated the pharmacokinetics and safety of fenofibrate in participants with mild hepatic impairment (phase 1 study) or advanced fibrosis due to metabolic‐associated fatty liver disease (MAFLD; phase 2a study).
Islam R. Younis, Elijah J. Weber, Cara Nelson, Ann R. Qin, Timothy R. Watkins, Ahmed A. Othman   +5 more
wiley   +1 more source

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

, 1995
Maria Z. Kounnas, Robert D. Moir, G. William Rebeck, Ashley I. Bush, W. Scott Argraves, Rudolph E. Tanzi, Bradley T. Hyman, Dudley K. Strickland   +7 more
openalex   +1 more source

Effects of a two‐night hospitalization program as a specific health guidance on obesity and cardiovascular disease risk factors

Journal of General and Family Medicine, EarlyView.
Abstract Background To assess the effects of a two‐night hospitalization program conducted at our hospital as part of a domestic health guidance system. This program is designed for lifestyle modification within a health checkup framework for metabolic syndrome. Methods This is a single‐center, retrospective observational study. We reviewed the medical
Maki Okazaki, Takeshi Katsuki, Hideaki Kurata, Shinichi Tanaka, Hajime Tanaka, Toshihide Kawai   +5 more
wiley   +1 more source