Results 31 to 40 of about 127,223 (162)

Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3′ untranslated region

Journal of Lipid Research, 1998
The mRNA encoding the human low density lipoprotein (LDL) receptor is transiently stabilized after phorbol ester treatment of HepG2 cells and has been shown to associate with components of the cytoskeleton in this cell line (G. M. Wilson, E. A.
G.M. Wilson, M.Z. Vasa, R.G. Deeley
doaj   +1 more source

Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.

Journal of Lipid Research, 1994
Familial defective apolipoprotein B-100 (FDB) is a genetic disorder apparently caused by a single amino acid substitution (Arg3500–>Gln) that disrupts the binding of low density lipoproteins (LDL) to the LDL receptor.
K S Arnold, M E Balestra, R M Krauss, L K Curtiss, S G Young, T L Innerarity   +5 more
doaj   +1 more source

Primary structure comparison of the proposed low density lipoprotein (LDL) receptor binding domain of human and pig apolipoprotein B: implications for LDL-receptor interactions

Journal of Lipid Research, 1988
Apolipoprotein B (apoB) is the predominant protein in low density lipoprotein (LDL) and is responsible for LDL binding to the LDL receptor. Although the primary amino acid sequence of human apoB has been determined, little is known about the structural ...
D L Ebert, N Maeda, S W Lowe, J Hasler-Rapacz, J Rapacz, A D Attie   +5 more
doaj   +1 more source

Development, food intake, and ethinylestradiol influence hepatic triglyceride lipase and LDL-receptor mRNA levels in rats.

Journal of Lipid Research, 1990
The influence of development and ethinylestradiol on low density lipoprotein (LDL)-receptor mRNA and hepatic triglyceride lipase (HTGL) activity and mRNA levels was studied in rat liver and intestine.
B Staels, H Jansen, A van Tol, G Stahnke, H Will, G Verhoeven, J Auwerx   +6 more
doaj   +1 more source

Calcium induces a conformational change in the ligand binding domain of the low density lipoprotein receptor

Journal of Lipid Research, 1998
We previously have shown that LDL-R354, a truncated low density lipoprotein (LDL) receptor, is a calcium binding protein. LDL-R354 is composed of the ligand binding domain and repeat A of the EGF precursor homology domain of the full-length human LDL ...
Kimberly A. Dirlam-Schatz, Alan D. Attie
doaj   +1 more source

Expression of low density lipoprotein receptor in cultured human granulosa cells: regulation by human chorionic gonadotropin, cyclic AMP, and sterol.

Journal of Lipid Research, 1990
Steroidogenic cells utilize lipoprotein-delivered cholesterol as a primary substrate for hormone synthesis. We studied low density lipoprotein (LDL) receptors in cultured human granulosa cells to determine what factors regulate receptor expression ...
T G Golos, A M August, J F Strauss, 3rd
doaj   +1 more source

Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: bone marrow transplantation studies in the mouse

Journal of Lipid Research, 1997
The targeted disruption of the low density lipoprotein (LDL) receptor gene in mice results in accumulation of plasma LDL cholesterol and in predisposition to diet-induced aortic atherosclerosis.
S Fazio, A H Hasty, K J Carter, A B Murray, J O Price, M F Linton   +5 more
doaj   +1 more source

Cholesteryl ester storage disease: complex molecular effects of chronic lovastatin therapy.

Journal of Lipid Research, 1992
To better characterize the in vivo effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition on human lipid metabolism, an adolescent male with cholesteryl ester storage disease (CESD) was treated chronically with lovastatin ...
R Levy, RE Ostlund, Jr, G Schonfeld, P Wong, CF Semenkovich   +4 more
doaj   +1 more source

Low density lipoprotein receptor degradation is influenced by a mediator protein(s) with a rapid turnover rate, but is unaffected by receptor up- or down-regulation

Journal of Lipid Research, 1988
Treatment of cultured human skin fibroblasts with cycloheximide retarded the down-regulation of low density lipoprotein (LDL) receptor activity caused by 25-hydroxycholesterol.
L A Casciola, D R van der Westhuyzen, W Gevers, G A Coetzee   +3 more
doaj   +1 more source

The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles

Journal of Lipid Research, 2012
ApoM is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL receptor deficiency is associated with increased plasma apoM in mice.
Christina Christoffersen, Marianne Benn, Pernille M. Christensen, Philip L.S.M. Gordts, Anton J.M. Roebroek, Ruth Frikke-Schmidt, Anne Tybjaerg-Hansen, Björn Dahlbäck, Lars B. Nielsen   +8 more
doaj   +1 more source