The role of proprotein convertase subtilisin/kexin type 9 inhibitors in managing cardiovascular risk
South African Family Practice, 2016 Hypercholesterolaemia and dyslipidaemia, marked by decreased levels of high-density lipoprotein and elevated levels of lowdensity lipoprotein (LDL), increase the risk of cardiovascular disease.
Natalie Schellack +2 more
doaj +1 more source
Thyrotropin modulates low density lipoprotein binding activity in FRTL-5 thyroid cells. [PDF]
, 1990 FRTL-5 cells possess high affinity low density lipoprotein (LDL) receptors which bind, internalize, and degrade LDL. When FRTL-5 cells are deprived of thyrotropin (TSH) the binding of LDL increases more than 2-fold.
Chiara Laezza +5 more
core +1 more source
Lipid metabolism in pancreatic cancer: emerging roles and potential targets
Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022 Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin +6 more
wiley +1 more source
Drug Delivery, 2020 Presently, a combination of chemotherapy, radiotherapy, thermotherapy, and other treatments has become a hot topic of research for the treatment of cancer, especially lung cancer.
Yan Shen +7 more
doaj +1 more source
Structural Properties of High and Low Density Water in a Supercooled Aqueous Solution of Salt [PDF]
J. Phys. Chem. B 115(6), 1461-1468 (2011), 2011 We consider and compare the structural properties of bulk TIP4P water and of a sodium chloride aqueous solution in TIP4P water with concentration c = 0.67 mol/kg, in the metastable supercooled region. In a previous paper [D. Corradini, M. Rovere and P. Gallo, J. Chem. Phys.
arxiv +1 more source
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor [PDF]
, 2002 Oxidatively modified low-density lipoprotein (ox-LDL) leads to endothelial activation, dysfunction and injury. Recently, a novel lectin-like receptor for ox-LDL (LOX-1) has been identified, primarily in the endothelial cells, and it allows uptake of ox ...
Li, Dayuan, Mehta, Jawahar L
core +1 more source
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
Nature Communications, 2017 Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL).
Camilla Gustafsen +13 more
semanticscholar +1 more source
СОХРАНЕНИЕ РЕЦЕПТОРОВ ЛПНП — НОВЫЙ ПОДХОД К ТЕРАПИИ ГИПЕРЛИПИДЕМИИ
Архивъ внутренней медицины, 2013 LDL receptor plays a key role in the metabolism of LDL cholesterol. It have been shown that proprotein convertase subtlisin/kexin type 9 is essential for post-transcriptional regulatation of the cell surface expression of the LDL receptor by ...
С. С. Бажан
doaj +1 more source
An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]
, 2018 Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances +2 more
core +2 more sources
Label Distribution Learning from Logical Label [PDF]
arXiv, 2023 Label distribution learning (LDL) is an effective method to predict the label description degree (a.k.a. label distribution) of a sample. However, annotating label distribution (LD) for training samples is extremely costly. So recent studies often first use label enhancement (LE) to generate the estimated label distribution from the logical label and ...
arxiv