Results 41 to 50 of about 226,507 (202)

Isoproterenol decreases LDL receptor expression in rat adipose cells: activation of cyclic AMP-dependent proteolysis

Journal of Lipid Research, 1996
The low density lipoprotein (LDL) receptor is part of a family of proteins that mediate the uptake of lipoproteins into cells. In this paper we have demonstrated the over-expression in E. coli of a rat LDL receptor fusion protein that contains the region
F B Kraemer, V Natu, A Singh-Bist, S Patel, M C Komaromy, S Medicherla, S Azhar, C Sztalryd   +7 more
doaj   +1 more source

Macrophage-mediated oxidation of extracellular low density lipoprotein requires an initial binding of the lipoprotein to its receptor.

Journal of Lipid Research, 1994
Cells of the arterial wall including macrophages were shown to oxidize low density lipoprotein (LDL) in vitro. Upon incubation of LDL with J-774.A1 macrophage-like cell line for 18 h in the presence of 1 microM CuSO4, extensive macrophage-mediated ...
M Aviram, M Rosenblat
doaj   +1 more source

A potential complication in the use of monoclonal antibodies: inhibition of apoB-mediated receptor binding by an anti-apoE antibody.

Journal of Lipid Research, 1989
Monoclonal antibody (Mab) 1D7 is specific for human apolipoprotein (apo) E and blocks binding of lipid-associated apoE to the low density lipoprotein (LDL) receptor. We report here that 1D7 can also block the binding of apoE-free LDL to the LDL receptor.
R Maurice, Y L Marcel, T L Innerarity, R W Milne   +3 more
doaj   +1 more source

Low density lipoprotein from humans supplemented with n-3 fatty acids depresses both LDL receptor activity and LDLr mRNA abundance in HepG2 cells.

Journal of Lipid Research, 1992
Fish oil supplementation in humans is often associated with an expanded low density lipoprotein (LDL) pool that is not thought to reflect increased production.
S Lindsey, A Pronczuk, KC Hayes
doaj   +1 more source

ELISA measurement of LDL receptors

Journal of Lipid Research, 1990
An enzyme-linked immunosorbent assay was developed for measurement of low density lipoprotein (LDL) receptors. A monospecific polyclonal antibody to LDL receptor purified from rat liver that reacted with rat, mouse, canine, and human LDL receptor was used.
K May, FB Kraemer, J Chen, AD Cooper
openaire   +3 more sources

Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.

Journal of Lipid Research, 1981
Improved techniques of cell isolation resulted in 90 to 100 million monocytes from a single donor. Addition of low density lipoprotein (LDL) to to cultures of these cells resulted in the down regulation of LDL receptor activity.
A M Fogelman, M E Haberland, J Seager, M Hokom, P A Edwards   +4 more
doaj   +1 more source

Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor

Journal of Lipid Research, 2007
LPL mediates the uptake of lipoproteins into different cell types independent of its catalytic activity. The mechanism of this process and its physiological relevance are not clear.
Britta Loeffler, Joerg Heeren, Mareike Blaeser, Herbert Radner, Daniel Kayser, Birol Aydin, Martin Merkel   +6 more
doaj   +1 more source

Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit.

Journal of Lipid Research, 1986
These studies were undertaken to determine the role of receptor-independent low density lipoprotein (LDL) transport in cholesterol balance across individual tissues and the whole animal.
D K Spady, M Huettinger, D W Bilheimer, J M Dietschy   +3 more
doaj   +1 more source

Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.

Journal of Lipid Research, 1994
Familial defective apolipoprotein B-100 (FDB) is a genetic disorder apparently caused by a single amino acid substitution (Arg3500–>Gln) that disrupts the binding of low density lipoproteins (LDL) to the LDL receptor.
K S Arnold, M E Balestra, R M Krauss, L K Curtiss, S G Young, T L Innerarity   +5 more
doaj   +1 more source

Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3′ untranslated region

Journal of Lipid Research, 1998
The mRNA encoding the human low density lipoprotein (LDL) receptor is transiently stabilized after phorbol ester treatment of HepG2 cells and has been shown to associate with components of the cytoskeleton in this cell line (G. M. Wilson, E. A.
G.M. Wilson, M.Z. Vasa, R.G. Deeley
doaj   +1 more source