Results 41 to 50 of about 2,625,160 (406)
Journal of Agricultural and Food Chemistry, 2014 Previous experiments in suitable animal models and in mild hypercholesterolemic individuals have shown that the consumption of lupin proteins may be useful for controlling total and low-density lipoprotein (LDL) cholesterol levels.
C. Lammi +4 more
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Nephrology, Dialysis and Transplantation, 2014 BACKGROUND Nephrotic syndrome (NS) leads to elevation of serum total and LDL cholesterol. This is largely due to impaired LDL clearance, which is caused by hepatic LDL receptor (LDLR) deficiency despite normal LDLR mRNA expression, pointing to a post ...
Shuman Liu, N. Vaziri
semanticscholar +1 more source
LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response [PDF]
, 2016 LDL receptor-related protein-1 (LRP1) is an endocytic and cell-signaling receptor. In mice in which LRP1 is deleted in myeloid cells, the response to lipopolysaccharide (LPS) was greatly exacerbated.
Azmoon, Pardis +5 more
core +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]
, 2008 Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R. +8 more
core +2 more sources
LDL Receptor and ApoE Are Involved in the Clearance of ApoM-associated Sphingosine 1-Phosphate*
Journal of Biological Chemistry, 2014 Background: A positive correlation exists between sphingosine 1-phosphate (S1P) and LDL cholesterol. Results: Hepatic LDL receptor overexpression decreased plasma S1P together with apoM in wild-type mice, but not in apoE-deficient mice.
M. Kurano +5 more
semanticscholar +1 more source
Towards Genetic Prediction of Coronary Heart Disease in Familial Hypercholesterolemia [PDF]
, 2009 Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipid metabolism caused by mutations in the gene coding for the low-density lipoprotein (LDL) receptor.
Net, J.B. (Jeroen) van der
core +1 more source
Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study [PDF]
, 2015 Objectives The interleukin-6 receptor (IL-6R) blocker tocilizumab (TCZ) reduces inflammatory disease activity in rheumatoid arthritis (RA) but elevates lipid concentrations in some patients.
Bathon, Joan M. +10 more
core +1 more source