Results 41 to 50 of about 127,223 (162)

Detection of the low density lipoprotein (LDL) receptor on nitrocellulose paper with colloidal gold-LDL conjugates.

Journal of Lipid Research, 1987
Gold-low density lipoprotein (LDL) conjugates were used to detect the LDL receptor on nitrocellulose paper. Solubilized rat liver membrane proteins were subjected to electrophoresis and electroblotted onto nitrocellulose paper.
P D Roach, M Zollinger, S P Noël
doaj   +1 more source

The beta-VLDL receptor pathway of murine P388D1 macrophages.

Journal of Lipid Research, 1988
Very low density lipoproteins Sf 100-400 (VLDL1) from hypertriglyceridemic (HTG) subjects and chylomicrons cause receptor-mediated lipid engorgement in unstimulated macrophages in vitro via the beta-VLDL receptor pathway.
S H Gianturco, S A Brown, D P Via, W A Bradley   +3 more
doaj   +1 more source

Minimally oxidized LDL inhibits macrophage selective cholesteryl ester uptake and native LDL-induced foam cell formation[S]

Journal of Lipid Research, 2014
Scavenger receptor-mediated uptake of oxidized LDL (oxLDL) is thought to be the major mechanism of foam cell generation in atherosclerotic lesions. Recent data has indicated that native LDL is also capable of contributing to foam cell formation via low ...
Jason M. Meyer, Ailing Ji, Lei Cai, Deneys R. van der Westhuyzen   +3 more
doaj   +1 more source

2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles[S]

Journal of Lipid Research, 2010
Several potentially atherogenic LDL subfractions present low affinity for the LDL receptor, which result in impaired plasma clearance. Electronegative LDL [LDL(−)] is one of these minor subfractions and the molecular basis for its reduced receptor ...
Francisco J. Blanco, Sandra Villegas, Sònia Benítez, Cristina Bancells, Tammo Diercks, Jordi Ordóñez-Llanos, José L. Sánchez-Quesada   +6 more
doaj   +1 more source

Identification of a novel Arg→Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs

Journal of Lipid Research, 1999
We previously carried out genetic and metabolic studies in a partially inbred herd of pigs carrying cholesterol-elevating mutations. Quantitative pedigree analysis indicated that apolipoprotein (apo)B and a second major gene were responsible for the ...
Kurt A.A. Grunwald, Kathryn Schueler, Patricia J. Uelmen, Beth A. Lipton, Mary Kaiser, Kimberly Buhman, Alan D. Attie   +6 more
doaj   +1 more source

Regulatory effects of n-3 polyunsaturated fatty acids on hepatic LDL uptake in the hamster and rat.

Journal of Lipid Research, 1995
These studies were undertaken to investigate the mechanisms involved in the regulation of hepatic low density lipoprotein (LDL) transport by n-3 fatty acids in the hamster and rat. Animals were fed n-3 or n-6 fatty acids with a cholesterol-free, very-low-
D K Spady, J D Horton, J A Cuthbert
doaj   +1 more source

ApoE is necessary and sufficient for the binding of large triglyceride-rich lipoproteins to the LDL receptor; apoB is unnecessary.

Journal of Lipid Research, 1986
Large triglyceride-rich very low density lipoproteins (VLDL) Sf 60-400 from hypertriglyceridemic (HTG) patients, but not VLDL from normal subjects, bind to the LDL receptor of human skin fibroblasts because they contain apolipoprotein E (apoE) of the ...
W A Bradley, S H Gianturco
doaj   +1 more source

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor

Journal of Lipid Research, 2005
Apolipoprotein E (apoE) associates with lipoproteins and mediates their interaction with members of the LDL receptor family. ApoE exists as three common isoforms that have important distinct functional and biological properties.
Jose Ruiz, Diana Kouiavskaia, Molly Migliorini, Susan Robinson, Evgueni L. Saenko, Natalia Gorlatova, Donghua Li, Daniel Lawrence, Bradley T. Hyman, Karl H. Weisgraber, Dudley K. Strickland   +10 more
doaj   +1 more source

Modified low density lipoprotein isolated from atherosclerotic lesions does not cause lipid accumulation in aortic smooth muscle cells.

Journal of Lipid Research, 1991
Foam cells in atherosclerotic lesions are derived not only from blood monocytes but also from smooth muscle cells (SMC). To better understand the mechanisms by which SMC may become lipid-laden, we have studied the catabolism by cultured rabbit aortic SMC
HF Hoff, JM Pepin, RE Morton
doaj   +1 more source

Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells*[S]

Journal of Lipid Research, 2009
LDL is the most abundant cholesterol transport vehicle in plasma and a major prognostic indicator of atherosclerosis. Hepatic LDL receptors limit circulating LDL levels, since cholesterol internalized by the liver can be excreted.
Noelle B. Vargas, Brandy Y. Brewer, Terry B. Rogers, Gerald M. Wilson   +3 more
doaj   +1 more source