Results 71 to 80 of about 2,605,698 (332)
PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment
Journal of Lipid Research, 2013 Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular degradation.
Kristian Tveten +3 more
doaj
Effect of probucol on LDL oxidation and atherosclerosis in LDL receptor-deficient mice [PDF]
Journal of Lipid Research, 1998 Probucol is a powerful inhibitor of atherosclerosis in a number of animal models. However, it is unknown whether this is due to the strong antioxidant protection of low density lipoprotein (LDL), to antioxidant effects in the artery wall, or to cellular effects not shared by other antioxidants. To investigate whether murine models are suitable to study
Bird, David A +5 more
openaire +6 more sources
The LDL receptor gene: a mosaic of exons shared with different proteins.
Science, 1985 The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains (LDL) receptor.
T. Südhof +3 more
semanticscholar +1 more source
Childhood Obesity and Familial Hypercholesterolemia: Genetic Diseases that Contribute to Cardiovascular Disease [PDF]
, 2014 Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency.
Caudle, Alyssa
core +1 more source
Journal of Lipid Research, 1990 We have reported the use of a retroviral vector to introduce the low density lipoprotein (LDL) receptor gene into receptor-deficient Watanabe heritable hyperlipidemic (WHHL) rabbit fibroblasts (Miyanohara, A., M. F. Sharkey, D. Steinberg, J. L.
MF Sharkey +4 more
doaj
Vector Space Morphology with Linear Discriminative Learning [PDF]
arXiv, 2021 This paper presents three case studies of modeling aspects of lexical processing with Linear Discriminative Learning (LDL), the computational engine of the Discriminative Lexicon model (Baayen et al., 2019). With numeric representations of word forms and meanings, LDL learns to map one vector space onto the other, without being informed about any ...
arxiv
A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K. +3 more
core +3 more sources
Journal of Lipid Research, 2000 We investigated the mechanism of β-very low density lipoprotein (β-VLDL)-induced foam cell formation derived from peritoneal macrophages from control mice and low density lipoprotein (LDL) receptor-deficient mice to elucidate the role of the LDL receptor
Nicole Herijgers +4 more
doaj
TabMixer: Excavating Label Distribution Learning with Small-scale Features [PDF]
arXiv, 2022 Label distribution learning (LDL) differs from multi-label learning which aims at representing the polysemy of instances by transforming single-label values into descriptive degrees. Unfortunately, the feature space of the label distribution dataset is affected by human factors and the inductive bias of the feature extractor causing uncertainty in the ...
arxiv
Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice [PDF]
Journal of Lipid Research, 2001 The low density lipoprotein receptor (LDLR) plays a major role in regulation of plasma cholesterol levels as a ligand for apolipoprotein B-100 and apolipoprotein E (apoE). Consequently, LDLR-deficient mice fed a Western-type diet develop significant hypercholesterolemia and atherosclerosis.
Masa-aki Kawashiri +5 more
openaire +4 more sources