Results 41 to 50 of about 14,838,699 (302)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Toxicity and gas chromatography-mass spectrometry analyses of a polyherbal formulation commonly used in Ibadan metropolis, Nigeria

open access: yesToxicology Reports, 2020
A polyherbal formulation mainly composed of Hibiscus sabdariffa and Aloe barbadensis commonly patronized by some staff and students of a College Hospital in Ibadan, Nigeria was evaluated for its toxicity status and bioactive constituents.
O.M. Ighodaro   +4 more
doaj   +1 more source

Magnetization of small lead particles

open access: yes, 2002
The magnetization of an ensemble of isolated lead grains of sizes ranging from below 6 nm to 1000 nm is measured. A sharp disappearance of Meissner effect with lowering of the grain size is observed for the smaller grains. This is a direct observation by
A. Frydman   +8 more
core   +2 more sources

Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models

open access: yesmAbs, 2020
The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provide ...
Feng Wang   +17 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Creating a more strategic small molecule biophysical hit characterization workflow

open access: yesSLAS Discovery
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns.
Christopher Fotsch   +11 more
doaj   +1 more source

Current Sensorless Control Algorithm for Single-Phase Three-Level NPC Inverter

open access: yesElectrical, Control and Communication Engineering, 2014
The current measurement is becoming a challenging task in power converters operating at high switching frequencies, moreover traditional control system requires two control loops - first (slow) regulates DC-link voltage, second (fast) controls the shape ...
Suzdalenko Alexander   +2 more
doaj   +1 more source

Performance Comparison of Power Divider and Fiber Splitter in the Fiber-Based Frequency Transmission System of Solar Radio Observation

open access: yesIEEE Access, 2021
Time-frequency synchronization plays an important role in the construction of solar radio telescopes (such as heliograph and interferometry). In the development of a synchronization system, time-frequency signal is divided and transmitted to each antenna
Yuqing Liu   +5 more
doaj   +1 more source

Opposite momenta lead to opposite directions [PDF]

open access: yes, 1999
When a particle decays into two fragments, the wavefunctions of the latter are spherical shells with expanding radii. In spite of this spherical symmetry, the two particles can be detected only in opposite directions.Comment: 3 pages LaTeX, submitted to ...
Peres, Asher
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

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