Results 61 to 70 of about 2,954,626 (283)

Climbing fiber burst size and olivary sub-threshold oscillations in a network setting.

PLoS Computational Biology, 2012
The inferior olivary nucleus provides one of the two main inputs to the cerebellum: the so-called climbing fibers. Activation of climbing fibers is generally believed to be related to timing of motor commands and/or motor learning.
Jornt R De Gruijl, Paolo Bazzigaluppi, Marcel T G de Jeu, Chris I De Zeeuw   +3 more
doaj   +1 more source

IMPORTANCE OF ELBOW FLEXOR MUSCLE STRENGTH AND ENDURANCE IN SPORTS CLIMBING [PDF]

Journal of Applied Sports Sciences, 2017
The muscles that exert most during sport climbing are the finger flexors followed by elbow flexors (EF). Nevertheless, climbers’ EF strength and endurance have not been tested in an isolated manner and EF endurance has not been assessed at ...
Michail Michailov, Stanislava Lambreva, Diana Deneva, Hristo Andonov   +3 more
doaj   +3 more sources

Accumulation and response to stress in climbing perch (Anabas testudineus) on exposure to high concentrations of lead and cadmium in water

The European Zoological Journal, 2022
Dans cette étude, le plomb (Pb) et le cadmium (Cd) ont été utilisés comme facteurs de stress chimiques. Des A. testudineus sains ont été exposés au Pb (20, 30 et 40 mg/L) et au Cd (3, 5 et 10 mg/L) pendant 7, 14, 21 et 28 jours pour évaluer la réponse de A. testudineus provoquée par ces métaux.
Dang Nguyen Nha Khanh, Ngo Thi Tuong Vy, Nguyêñ Quôć Thăńg, Do Trung Sy, Bùi Quang Minh, N. The Anh, Dang Vu Bao Tran, L. Khue Tu, Nguyen Thi Kim Phuong   +8 more
openaire   +2 more sources

Climbing Accidents—Prospective Data Analysis from the International Alpine Trauma Registry and Systematic Review of the Literature [PDF]

, 2019
Climbing has become an increasingly popular sport, and the number of accidents is increasing in parallel. We aim at describing the characteristics of climbing accidents leading to severe (multisystem) trauma using data from the International Alpine ...
Wallner, Bernd, Simon Rauch, Ströhle, Mathias, Rauch, Simon, Mathias Ströhle, Monika Brodmann Maeder, Brodmann Maeder, Monika, Bernd Wallner, Tomas Dal Cappello, Dal Cappello, Tomas   +9 more
core   +2 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A memetic algorithm with adaptive hill climbing strategy for dynamic optimization problems [PDF]

, 2009
Copyright @ Springer-Verlag 2008Dynamic optimization problems challenge traditional evolutionary algorithms seriously since they, once converged, cannot adapt quickly to environmental changes. This paper investigates the application of memetic algorithms,
Wang, H, Yang, S, Wang, Dingwei, Yang, Shengxiang, Wang, Hongfeng, Wang, D   +5 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Gaze Control and Foot Kinematics During Stair Climbing: Characteristics Leading to Fall Risk in Progressive Supranuclear Palsy [PDF]

Physical Therapy, 2008
Background and PurposeDoes gaze control influence lower-extremity motor coordination in people with neurological deficits? The purpose of this study was to determine whether foot kinematics during stair climbing are influenced by gaze shifts prior to stair step initiation.Subjects and MethodsTwelve subjects with gaze palsy (mild versus severe ...
Richard P, Di Fabio, Cris, Zampieri, Paul, Tuite   +2 more
openaire   +2 more sources