Results 71 to 80 of about 2,954,626 (283)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Forearm muscle and nerve morphology differs by sex and predicts climbing style in recreational climbers

Scientific Reports
Climbing is a physically demanding discipline that places repetitive mechanical load on the upper limbs, potentially leading to morphological adaptations or overuse injuries.
Harryson Emmanuel Caro-Betancur, María Bravo-Aguilar, María Estrella-Riquelme, Daniela Jiménez-Parra, Ángel González-de-la-Flor, Daniel López-López, Mónica García-Mateos, Diego Miñambres-Martín, Gonzalo Jaén-Crespo, Carlos Romero-Morales   +9 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Oxygen kinetics as predictors for sport climbing performance : climbing-specific test on a climbing treadwall

, 2022
The multifaceted nature of climbing as a sport lead to varying physiological demands. Alt-hough some multiple factors are known which influences climbing performance, the exact mechanisms remain unclear.
Konermann, Leonie Simone
core   +2 more sources

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Correcting Human Errors in Rock Climbing [PDF]

, 2019
In the sport of rock climbing, improper belay technique resulting from the belayer standing too far from the wall is a main source of accidents and injuries from lead climbing. This project aimed to correct human errors in lead belaying and climbing. The
Yan, Regina
core  

Pengaruh Metode Latihan Pull Up Dan Metode Latihan Single Rope TechniqueTerhadap Hasil Pemanjatan Lead Atlet Sport Climbing

, 2022
Pull up dan metode latihan SRT merupakan variasi latihan yang sering digunakan pada sport climbing Tujuan penelitian ini untuk mengetahui latihan tersebut terhadap hasil pemanjatan lead atlet di kota Palembang.
Senna, Haris Mastun, Fikri, Aprizal, Endrawan, I Bagus, Kesumawati, Selvi Atesya, Sukmawati, Noviria, Hardiyono, Bayu   +5 more
core   +2 more sources

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Tree Climbing Specialists Lead Introduction to Climbing

, 2019
Morthera, Cassandra. (2019). Tree Climbing Specialists Lead Introduction to Climbing.
Morthera, Cassandra
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source