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Scintillation proximity assay in lead discovery
Expert Opinion on Drug Discovery, 2008Scintillation proximity assay (SPA) is a homogeneous scintillant bead-based platform for the measurement of biological processes and plays an important role in the identification of active chemical entities in drug discovery.The design and development of solid-phase SPA approaches are examined and compared with alternative non-radiometric fluorescence ...
Xavier, Khawaja +2 more
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Fragment-Based Lead Discovery and Design
Journal of Chemical Information and Modeling, 2014Fragment-based lead discovery and design has and continues to show increasing promise in drug discovery. In this article, the current state of the art in terms of hot-spot characterization, fragment screening techniques, and fragment-based design is discussed. Three overall fragment-based lead generation strategies are explored and involve the chemical
Diane, Joseph-McCarthy +3 more
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The antibacterial lead discovery challenge
Nature Reviews Drug Discovery, 2010openaire +3 more sources
Discovery of three lead-rich stars
Nature, 2001About half of the stable nuclei heavier than iron are believed to be synthesized during the late stages of evolution of stars with masses in the range 0.8-8 solar masses. These elements are then expelled into the interstellar medium through stellar winds after being 'dredged up' towards the surface of the stars.
Van Eck, Sophie +3 more
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Modern Drug Discovery Technologies: Opportunities and Challenges in Lead Discovery
Combinatorial Chemistry & High Throughput Screening, 2011The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have revitalized the screening process model and emphasized the importance of exploring the intrinsic complementary nature of classical and ...
Rafael V C, Guido +2 more
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Discovery Toxicology in Lead Optimization
2023Toxicity remains a leading cause of attrition at all stages of the drug development process. The majority of safety-related attrition occurs preclinically, suggesting that approaches to identify “predictable” preclinical safety liabilities earlier in the drug development process should lead to the design and/or selection of better drug candidates that ...
Stefano Fontana +7 more
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Drug Discovery Biology Leading Biophotonics
Asia Optical Fiber Communication and Optoelectronic Exposition and Conference, 2008Discussed are enabling biophotonic technologies that provide in-vivo like information earlier in drug discovery. The development of resonant waveguide sensor based high-throughput screening platform and utilization for studying signaling in cells will be described.
Ye Fang +3 more
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Chemical space navigation in lead discovery
Current Opinion in Chemical Biology, 2002The number of new chemical entities has remained rather constant (averaging 37 per year) in the past decade, despite the multiple-fold increase in the number of compounds that are being made and tested. Chemical space requires novel methods that can handle the increasing number of potentially accessible molecules.
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Experiences in Fragment-Based Lead Discovery
2011This chapter summarizes the experience at Vernalis over the past decade in developing and applying fragment-based discovery methods across a range of different targets. The emphasis will be on the practical aspects of the different biophysical techniques (surface plasmon resonance (SPR), differential scanning fluorimetry (DSF), isothermal titration ...
Roderick E, Hubbard, James B, Murray
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2018
This chapter explores pragmatic leadership skills and how they help achieve innovation. It shows how ideationally competent leaders support the internal process of innovation by picking up contextual cues in the environment and exploring the signals and trends, obstacles and challenges. They have the ideational competence to create the sense of sharing,
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This chapter explores pragmatic leadership skills and how they help achieve innovation. It shows how ideationally competent leaders support the internal process of innovation by picking up contextual cues in the environment and exploring the signals and trends, obstacles and challenges. They have the ideational competence to create the sense of sharing,
openaire +1 more source