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Target information in lead discovery
TARGETS, 2003Abstract Effective categorization and description of targets is as important during lead discovery as it is during target identification and validation. The selection of targets to progress to lead identification, the efficiency of assay development, and the analysis of results from compound testing all benefit from the availability of high-quality ...
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Drug discovery: finding a lead
2023This chapter looks at what happens from the moment that a pharmaceutical company or university research group initiates a new medicinal chemistry project through to the identification of a lead compound. It focuses on pharmaceutical companies which tend to concentrate on developing drugs for diseases prevalent in developed countries.
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Lead Discovery and Lead Modification
2014Richard B. Silverman, Mark W. Holladay
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Adding calorimetric data to decision making in lead discovery: a hot tip
Nature Reviews Drug Discovery, 2009John Edward Ladbury +2 more
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Innovative lead discovery strategies for tropical diseases
Nature Reviews Drug Discovery, 2006Solomon Nwaka
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Twenty years on: the impact of fragments on drug discovery
Nature Reviews Drug Discovery, 2016Daniel A Erlanson +2 more
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