Results 101 to 110 of about 3,479,224 (308)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Alexander L. Gerbes, Aoyama, Barak, Bressac, Bressac, Buetow, Caselmann, Challen, Colombo, Donehower, Fields, Finlay, Foster, Halevy, Hsu, Jenkins, Kastan, Kekulé, Kew, Kress, Lane, Laurent-Puig, Lilleberg, Livingstone, Ludlow, Malkin, Marshall, Meyer, Meyer, Mueller, Murakami, Nigro, Ozturk, Raycroft, Sarnow, Slagle, Srivastava, Sturzbecher, Taylor, Wolfgang H. Caselmann, Wollersheim   +40 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Enacting the 'true self': Towards a theory of embodied authentic leadership [PDF]

, 2010
This paper argues that although authentic leadership may be rooted in the notion of a ‘true self’, it is through the embodiment of that ‘true self’ that leaders are perceived as authentic or not.
Ladkin, Donna, Taylor, S.
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Occupational lead exposure and its dual impact on renal function and reproductive hormones: A case-control study of Nigerian battery chargers

Journal of Allied Health Sciences & Medical Research
Occupational lead exposure among battery chargers poses significant risks to renal and reproductive health. This study assessed serum markers of kidney function (urea, creatinine, uric acid) and reproductive hormones (luteinizing hormone [LH ...
Ganiyu O. Adeosun, Abdullahi O. Olawuyi, Regina M. Oboh, Fatai O Salawudeen, Tonia C. Onyeneke, Hassanat A. Adeosun   +5 more
doaj   +1 more source

Impaired Antioxidant-Defence Status in Nigerian Children with Elevated Blood Lead Levels: A Possible Predisposing Factor to Chronic Diseases. [PDF]

Journal of Krishna Institute of Medical Sciences University, 2020
Background: Lead, a prime environmental toxicant and multi-organ poison, exerts its toxicity through interaction with essential metals and the generation of free radicals.
Nnenna L. Nwobi, Joseph C. Nwobi, Michael O. Akinosun, Nnodimele O. Atulomah, Ikechukwu A. Nwazuoke, John I. Anetor   +5 more
doaj  

Effects of Chlordiazepoxide on Predator Odor-Induced Reductions of Playfulness in Juvenile Rats

, 2010
The extent to which a non-sedative dose of chlordiazepoxide (CDP) is able to modify the behavioral responses toward a predator odor was assessed in juvenile rats.
DeBrouse, Lauren M., Siviy, Stephen M., Steets, Courtney L.   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Ease Leads to Exposure. Exposure Leads to Adoption

, 2019
ESIP Summer Meeting 2019 plenary remarks about getting people to actually USE the resources that we’ve worked so very hard to build, and thus is in keeping with the conference theme: “Data to Action: Increasing the Use and Value of Earth Science Data and Information.” As we seek to increase the USE and VALUE of Earth science data and information, a ...
openaire   +1 more source