Results 121 to 130 of about 3,479,224 (308)

THE INFLUENCE OF MERCURY POLLUTION ON THE GROWTH OF BIO-INDICATOR PLANTS [PDF]

, 2018
Heavy metals are found naturally in the earth, and become concentrated as a result of human caused activities. Common sources are from mining and industrial wastes, vehicle emissions, lead- acid batteries, fertilisers, paints, treated woods, aging ...
Kalinina, Katerina, Kovrov, Oleksandr
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The level of blood lead, zinc and relationship with the metallothionein gene polymorphism in chronic kidney failure

Počki
Background. Chronic kidney disease is defined by renal damage or an estimated glomerular filtration rate less than 60 ml/min/1.73 m2. Lead is a ubiquitous environmental factor that can contribute to lengthy clinical complications in individuals with ...
Arwa M. Nasser, Essam F. Al-Jumaili
doaj   +1 more source

Distribution of contaminants in the environment and wildlife habitat use: a case study with lead and waterfowl on the Upper Texas Coast [PDF]

, 2019
The magnitude and distribution of lead contamination remain unknown in wetland systems. Anthropogenic deposition of lead may be contributing to negative population-level effects in waterfowl and other organisms that depend on dynamic wetland habitats ...
Conway, Warren C., Haukos, David A., Kearns, Brian, McDowell, Stephen, Moon, Jena A., Rigby, Elizabeth   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effect of vitamin C and quercetin treatment on the liver histopathologic profile in congenital lead exposed male rat pups [PDF]

, 2015
Introduction: Lead is one of the most important environmental pollutants due to its vast use in various industries. Lead accumulation in different organs, especially the brain, liver and kidneys can cause serious health problems.
Beheshti, N., Ganji, F., Sepehri, H.
core  

DNA Breathing Dynamics in the Presence of a Terahertz Field

, 2009
We consider the influence of a terahertz field on the breathing dynamics of double-stranded DNA. We model the spontaneous formation of spatially localized openings of a damped and driven DNA chain, and find that linear instabilities lead to dynamic ...
A. Usheva, A.R. Bishop, Alexandrov, Alexandrov, Alexandrov, B.S. Alexandrov, Bondar, Brucherseifer, Chu, Chu, Dauxois, Frohlich, George, Ho, Homenko, Ince, K.Ø. Rasmussen, Korenstein-Ilan, Lie George, Markelz, Olshevskaya, Olshevskaya, Peyrard, Samson, Usheva, V. Gelev, Vanossi, Verschaeve, Whittaker   +28 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

High Blood Lead Levels as A Risk Factor of Stunting: A Study of Children in Agricultural Areas

Jurnal Kesehatan Lingkungan
Introduction: The prevalence of stunting among student aged children in Indonesia is relatively high (24.5%). Stunting can threaten the quality of human resources one day.
Alfan Afandi, Suhartono Suhartono, Budiyono Budiyono, Ani Margawati, Apoina Kartini   +4 more
doaj   +1 more source