Results 131 to 140 of about 1,521,832 (315)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Memory Functions in Recreational Pistol Sport Shooters: Does Lead Matter?

Environmental Health Insights, 2009
Objective: The aim of our study was to examine the memory functions of pistol sport shooters using powder charges when exposure to lead is expected to be considerably lower than in occupational circumstances.Methods: A neuropsychological battery of ...
Sanna Asa-Mäkitaipale, Mervi Jehkonen, Jukka Uitti, Juhani Vilkki   +3 more
doaj  

Oxidative Stress, DNA Damage, DNA Repair Inhibition, and Apoptosis Induced by Lead and Cadmium Combined Exposure in TK6 Cells

Toxics
Lead (Pb) and cadmium (Cd) are common environmental pollutants. Our previous population study revealed a significant positive association between Pb and Cd exposure and the micronuclei frequency among lead smelting workers.
Xin Liu, Zhiyuan Han, Kuibin Han, Yuhan Pang, Xiaoyue Zhao, Yuting Wang, Xiaoyan Wu, Tuanwei Wang   +7 more
doaj   +1 more source

Monetary benefits of preventing childhood lead poisoning with lead-safe window replacement

Previous estimates of childhood lead poisoning prevention benefits have quantified the present value of some health benefits, but not the costs of lead paint hazard control or the benefits associated with housing and energy markets. Because older housing
Berg, Michael, Jacobs, David / E., Cohen, Jonathan, Nevin, Rick   +3 more
core  

Lead in air, soil, and blood [PDF]

lead-in-air-soil-and-blood-may-2022-508 ...

core  

Development and application of an inhalation bioaccessibility method (IBM) for lead in the PM10 size fraction of soil

, 2014
An approach for assessing the inhalation bioaccessibility of Pb in the PM10 size fraction is presented, using an in vitro simulated epithelial lung fluid to represent the extracellular environment of the lung.
Boisa, N., Entwistle, J.A., Dean, John R., Elom, N., Bird, Graham, Bird, G., Dean, John, Entwistle, Jane A., Bird, Dick, Deary, Michael E., Entwistle, Jane, Dean, J.R., Boisa, Ndokiari, Elom, Nwabueze, Deary, Michael, Deary, M.E.   +15 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Demographic differences in exposure to toxic trace elements in urban South Africa during the 20th century.

Exposure to toxic elements is a significant threat to public and individual health worldwide. Toxic elements such as heavy metals are associated with increased mortality and morbidity in both men and women and are a substantial contributor to ...
Hess, Catherine
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DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Understanding international crime trends: The legacy of preschool lead exposure

This study shows a very strong association between preschool blood lead and subsequent crime rate trends over several decades in the USA, Britain, Canada, France, Australia, Finland, Italy, West Germany, and New Zealand. The relationship is characterized
Nevin, Rick
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