Results 181 to 190 of about 3,458,304 (355)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Impact of intermittent lead exposure on hominid brain evolution. [PDF]

Sci Adv
Joannes-Boyau R, de Souza JS, Arora M, Austin C, Westaway K, Moffat I, Wang W, Liao W, Zhang Y, Adams JW, Fiorenza L, Dérognat F, Moncel MH, Schwartz GT, Bailey M, Dos Santos FF, Guardia GDA, Mercuri RLV, Galante PAF, Martins AMA, Tsu BL, Barnes CA, Yates J, Petroski LP, Sanchez-Sanchez SM, Oviedo J, Herai RH, Lemos B, Tonge M, Muotri AR.   +29 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A community-based participatory research program to identify lead exposure risks and community priorities. [PDF]

Discov Soc Sci Health
Zavala-Garcia J, Ali N, Arango O, Brady C, Esquivel-Cote R, Goldsmith ST, Link H, Lugo D, Matos S, McDermott-Levy R, Shakya KM, Smith DJ, CCATE Círculo de Salud .   +12 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Lead exposure in sandblasting. [PDF]

, 1992
Ellen K. Silbergeld
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Renal effects of environmental and occupational lead exposure.

, 1997
Mahmoud Loghman‐Adham
openalex   +1 more source

Single cell analysis of the effects of developmental lead (Pb) exposure on the hippocampus [PDF]

, 2019
Kelly M. Bakulski, John Dou, Robert C. Thompson, Christopher Lee, Lauren Y. M. Middleton, Bambarendage P. U. Perera, Sean P. Ferris, Tamara R. Jones, Kari Neier, Xiang Zhou, Maureen A. Sartor, Saher Sue Hammoud, Dana C. Dolinoy, Justin A. Colacino   +13 more
openalex   +1 more source