Results 191 to 200 of about 1,521,832 (315)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Lead exposure in relation to gut homeostasis, microbiota, and metabolites. [PDF]

Appl Environ Microbiol
Tao Y, Liu D, Shi Q, Sun Q, Liu C, Zeng X.   +5 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Prenatal and Early Postnatal Lead Exposure and Later Adulthood Cognitive Function in the St. Louis Baby Tooth-Later Life Health Study. [PDF]

Neurology
Hickman RC, Lin JJY, McAlaine KA, Punshon T, Jackson BP, Bidlack FB, Germine LT, Bartell SM, Mangano JJ, Farmer J, Schwartz J, Mukherjee R, Korrick SA, Weisskopf MG.   +13 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Identifying critical windows of susceptibility to perinatal lead exposure on child serum vaccine antibody levels. [PDF]

Am J Epidemiol
Colicino E, Feiler MO, Austin C, Rosa MJ, McRae N, Quataert SA, Thevenet-Morrison K, Téllez-Rojo MM, Lamadrid-Figueroa H, Tavarez ZQ, Shim YK, Arora M, Wright RO, Jusko TA.   +13 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Lead exposure is associated with increased lead bioaccumulation and a decline in semen quality: a systematic review and meta-analysis. [PDF]

JBRA Assist Reprod
Adisa VI, Ashonibare PJ, Adegbola CA, Akhigbe TM, Kolawole OR, Omole IA, Fidelis FB, Adeogun AE, Oluwole RP, Akorede BA, Ogunkola BD, Adekunle AO, Hassan SA, Mansur SS, Ajeigbe SB, Oyedokun PA, Ashonibare VJ, Adelowo OE, Oyesetan RI, Oladipo AA, Akhigbe RE.   +20 more
europepmc   +1 more source

Reducing Workers\u2019 Lead Exposure during Water Service Line Removal and Replacement

Workers who replace lead water service lines may be exposed to lead pipes and lead-contaminated soil while removing the old water lines and replacing them with lead-free lines.

core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source