Results 171 to 180 of about 1,521,832 (315)

Impact of intermittent lead exposure on hominid brain evolution. [PDF]

Sci Adv
Joannes-Boyau R, de Souza JS, Arora M, Austin C, Westaway K, Moffat I, Wang W, Liao W, Zhang Y, Adams JW, Fiorenza L, Dérognat F, Moncel MH, Schwartz GT, Bailey M, Dos Santos FF, Guardia GDA, Mercuri RLV, Galante PAF, Martins AMA, Tsu BL, Barnes CA, Yates J, Petroski LP, Sanchez-Sanchez SM, Oviedo J, Herai RH, Lemos B, Tonge M, Muotri AR.   +29 more
europepmc   +1 more source

The Change of β-Adrenergic System after Cessation of Lead Exposure

, 2008
For understanding a reversible or irreversible harm of β- adrenergic system in lead induced cardiovascular disease ( hypertension), We set up animal model to estimate the change of blood pressure and sympathetic nervous system after lead exposure ...
CHANG, HUOY-ROU;TSAO, DER-AN;YU, HSIN-SU;HO, CHI-KUNG, 張慧柔;曹德安;余幸司;何啟功   +1 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Lead exposure across early life in Latin America and the Caribbean: prevention strategies and reproductive health considerations. [PDF]

Front Reprod Health
Boda M, Pereira EC, Lima ELSC, Olympio KPK.   +3 more
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Global burden of cardiovascular disease attributable to lead exposure: based on the global burden of disease study 2021. [PDF]

Front Public Health
Lin Z, Zhang Z, Zeng Q, Luo S, Xu J.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Lead exposure increases the risk of retinal vein occlusion: a population-based analysis and investigation of PRICKLE4/PLCXD1-mediated endothelial cell mechanisms. [PDF]

Front Public Health
Yang S, Xu L, Chen T, Yao T, Zhang X, Wang J, Wang Z.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source