Results 61 to 70 of about 18,301 (240)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Diskursus Hermeneutik dalam Paradigma Keislaman dan Kemodernan

Substantia: Jurnal Ilmu-Ilmu Ushuluddin, 2015
Muslim scholars’ interests on hermeneutic have led to the development of the Al-Quran interpretation into various models. Hermeneutic has become the icon in modernization of Al-Quran values in which interpretation revolves around transnational and ...
Nurkhalis Nurkhalis
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Consolidation of Degraded Lime Wooden Support from Heritage Objects Using Two Types of Consolidant

BioResources, 2023
The novelty of the research consists in the fact that the decayed wood was taken from an old icon, on which several consolidation treatments were applied, and the improvement indices of the decayed wood (by Anobiidae insects) were also determined.
Anamaria Avram, Constantin Ionescu, Aurel Lunguleasa   +2 more
doaj   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Mother of God of the Kanikleion

Greek, Roman, and Byzantine Studies, 2001
The lead seal of the 11th/12th century here published offers an image of the Virgin Kiriotissa, but the inscription gives Kanikliotisa; this must invoke an icon of Mary that would have been in the Kanikleion monastery.
George P. Galavaris
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Machine Learning-Based Identification of Key Predictors for Lightning Events in the Third Pole Region

ISPRS International Journal of Geo-Information
The Third Pole region, particularly the Hindu–Kush–Himalaya (HKH), is highly prone to lightning, causing thousands of fatalities annually. Skillful prediction and timely communication are essential for mitigating lightning-related losses in such ...
Harshwardhan Jadhav, Prashant Singh, Bodo Ahrens, Juerg Schmidli   +3 more
doaj   +1 more source

Gran Torinoís Hmong Lead Bee Vang on Film, Race and Masculinity [PDF]

Hmong Studies Journal, 2010
Bee Vang, of Minneapolis, played the Hmong lead Thao Vang Lor in Clint Eastwood's 2008 Gran Torino. He was sixteen when he shot the film and had no acting training.
Louisa Schein
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source