Results 161 to 170 of about 384,964 (298)

India - a lead market for frugal innovations? Extending the lead market theory to emerging economies [PDF]

India has emerged as a vibrant and versatile source for cost effective, disruptive innovations of various varieties. Price-sensitive consumers in a large and growing market keep inducing firms to apply frugal engineering for creating affordable products ...
Herstatt, Cornelius, Tiwari, Rajnish
core  

Turning the tables: creating space for lived experience leadership in research. [PDF]

Res Involv Engagem
Morrison LT, McGlade A, Kirk CA, Burnside I, Davidson G.   +4 more
europepmc   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Lead User : Definition und die Rolle im Marketing der Unternehmen

, 2015
Die vorliegende Bachelorarbeit beschreibt die Lead-User-Methode. Dabei werden die Merkmale eines fortschrittlichen Kunden (Lead-Users) dargestellt, sowie die Phasen des Innovationsprozesses mit integrierter Identifikation der Lead-User.
Schütz, Christopher
core  

A Smart Textile Biofeedback Training System for Upper Limb Rehabilitation After Stroke: Co-Design Development and Evaluation Study. [PDF]

JMIR Rehabil Assist Technol
Munoz-Novoa M, Guo L, Björkquist A, Kristoffersen MB, Khorramshahi P, Sandsjö L, Alt Murphy M.   +6 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

EMERALD-UI: an interactive web application to unveil novel protein biology hidden in the alternative alignment space. [PDF]

Bioinformatics
Preoteasa A, Grigorjew A, Tomescu AI, Drost HG.   +3 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

How a Fee Per-Unit Garbage Affects Aggregate Recycling in a Model with Heterogeneous Households [PDF]

This paper develops a utility maximizing model of household choice among garbage disposal, recycling, and littering. The impact of a user fee for garbage collection is modelled for heterogeneous households with different preferences for recycling.
Don Fullerton, Thomas C. Kinnaman
core  

<i>P.I. Charter</i>: A Shiny Application for Collecting, Cleaning, Compiling, and Communicating Point-Intercept Aquatic Plant Data. [PDF]

Ecol Evol
Bajcz AW, Larkin DJ, Verhoeven MR, Newman RM, Walsh JR, Panda A, Phelps NBD.   +6 more
europepmc   +1 more source