Results 91 to 100 of about 860,270 (308)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

How and why eLife selects papers for peer review

eLife
When deciding which submissions should be peer reviewed, eLife editors consider whether they will be able to find high-quality reviewers, and whether the reviews will be valuable to the scientific community.
eLife Editorial Leadership, eLife Senior Editors, eLife Early Career Advisory Group   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Leadership Innovation and Inclusion in the City of Big Shoulders

, 2019
Ever wonder how our emerging leaders frame and think about leadership? That insight could help us understand the future of leadership while revealing key priorities for leadership education, development, and research.
Cletzer, D. Adam, Alegbeleye, Ibukun Dami, Kaufman, Eric K.   +2 more
core  

Learning Leadership: A Qualitative Study on the Differences of Student Learning in Online versus Traditional Courses in a Leadership Studies Program

, 2017
As online education offerings are extended to more students, organizations are increasingly interested in the effectiveness of online learning compared to a traditional classroom.
Amber Manning-Ouellette,, Manning-Ouellette, Amber, Katie M. Black, Black, Katie   +3 more
core   +1 more source

Contemporary Public Leadership In China: A Research Review and Consideration [PDF]

, 2005
Background China’s economic and political importance has captured the world’s attention. China has become increasingly integrated into the global economy.
Pittinsky, Todd L., Zhu, Cheng, Cheng Zhu, Todd L. Pittinsky   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

[Letter from Leadership Lambda Seminar to Leadership Lambda Seminar Series Participant, January 19. 1999]

, 1999
Letter to Leadership Lambda Seminar Series Participant, January 19. 1999. The letter is an invitation to an unnamed participant for Session Six of the Seminar Series: Understanding Organizations: The Nuts and ...
Leadership Lambda, Inc.
core   +1 more source

Community Food Bank of Southern Arizona's Michael McDonald on Leadership

, 2016
Peer Reviewed by Christina R. Kalel / Edited by Dr. Brandy A. Brown and Romi C. WittmanThis paper analyzes Michael McDonald, a leader in the nonprofit sector in Tucson, Ariz., through the lens of leadership effectiveness.
Glockner, Erin
core