Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
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Social Sciences and Humanities OpenThis article presents a qualitative system analysis informing public policy advancement for workplace psychological violence injury. It is a unique look into how a jurisdiction responds to the injury caused by workplace psychological violence (workplace ...
Wendy Bigcharles-Gaucher
doaj
Servant leadership and patient safety culture in Ethiopian public hospitals: a qualitative study. [PDF]
BMC Health Serv ResDemeke GW, van Engen ML, Markos S.
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
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Examination of the relationship between perceived freedom levels in leisure time and multidimensional leadership orientations of individuals engaged in nature sports as a recreational activity. [PDF]
Front PsycholKoç K +6 more
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Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?
Molecular Oncology, EarlyView.Chen‐xi Li, Zhong‐cheng Gong
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Development of medical leadership competence during undergraduate medical students' final year - a cross-sectional cohort study. [PDF]
BMC Med EducOgurek B, Harendza S.
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Alcorn College and Its Graduates – a Case Study in Negro Leadership
, 1933 Walker Milan Davis
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Creative Leadership, by R. Bellows, Englewood Cliffs, N.J., Prentice-Hall, 1959. [PDF]
, 1960 Robin Giroux
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