Results 41 to 50 of about 398,051 (262)

Editors’ Letter, Volume 1, Issue 2

open access: yesLeaf Journal, 2023
Managing Editors Elen Caldecott and Lucy Cuthew introduce the articles and papers presented in this issue of 'Leaf Journal', many of which were presented at our inaugural conference.
Lucy Cuthew, Elen Caldecott
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Fresh Meat Sold in Five Markets in Luanda (Angola): Food Quality and Safety, Knowledge, and Practices of the Sellers

open access: yesJournal of Food Quality
Consumption of contaminated meat and meat by-products has been associated with several foodborne outbreaks worldwide. Particularly in informal markets, poor hygiene during slaughter, transportation, and sale, as well as inadequate sanitation at points of
Gomes Cahango   +6 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

The Post-Apocalyptic Space, Character, and Morality in Middle-Grade Children’s Literature

open access: yesLeaf Journal, 2023
Stories for young readers overwhelmingly aim to educate on what is good and how a person must behave as a moral member of society. The question of how characters may further solidify moral right and wrong in the post-apocalyptic setting of my story The ...
Vlad Marinescu
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Tetraselmis chuii as a Sustainable and Healthy Ingredient to Produce Gluten-Free Bread: Impact on Structure, Colour and Bioactivity

open access: yesFoods, 2020
The objective of this work is to increase the nutritional quality of gluten-free (GF) bread by addition of Tetraselmis chuii microalgal biomass, a sustainable source of protein and bioactive compounds. The impact of different levels of T.
Maria Cristiana Nunes   +4 more
doaj   +1 more source

Preliminary results on tartaric stabilization of red wine by adding different carboxymethylcelluloses [PDF]

open access: yesCiência e Técnica Vitivinícola, 2018
Despite being natural phenomena of physical-chemical stabilization of young wines, tartrate precipitations in bottled wines are often understood as a quality fault.
Pittari Elisabetta   +3 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

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